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- Zbynek Bozdech, Manuel Llinás, Brian Lee Pulliam, Edith D. Wong, Jingchun Zhu, Joseph L. DeRisi
- PLoS biology
- 2003
Plasmodium falciparum is the causative agent of the most burdensome form of human malaria, affecting 200-300 million individuals per year worldwide. The recently sequenced genome of P. falciparum… (More)
- Thomas Dan Otto, Daniel Wilinski, +9 authors Manuel Llinás
- Molecular microbiology
- 2010
Recent advances in high-throughput sequencing present a new opportunity to deeply probe an organism's transcriptome. In this study, we used Illumina-based massively parallel sequencing to gain new… (More)
- Erandi K. De Silva, Andrew R. Gehrke, +4 authors Manuel Llinás
- Proceedings of the National Academy of Sciences…
- 2008
Malaria remains one of the most prevalent infectious diseases worldwide, affecting more than half a billion people annually. Despite many years of research, the mechanisms underlying transcriptional… (More)
- Tracey L. Campbell, Erandi K. De Silva, Kellen L. Olszewski, Olivier Elemento, Manuel Llinás
- PLoS pathogens
- 2010
The molecular mechanisms underlying transcriptional regulation in apicomplexan parasites remain poorly understood. Recently, the Apicomplexan AP2 (ApiAP2) family of DNA binding proteins was… (More)
- Manuel Llinás, Zbynek Bozdech, Edith D. Wong, Alex T. Adai, Joseph L. DeRisi
- Nucleic acids research
- 2006
Gene expression patterns have been demonstrated to be highly variable between similar cell types, for example lab strains and wild strains of Saccharomyces cerevisiae cultured under identical growth… (More)
- Björn F. C. Kafsack, Núria Rovira-Graells, +9 authors Manuel Llinás
- 2014
The life cycles of many parasites involve transitions between disparate host species, requiring these parasites to go through multiple developmental stages adapted to each of these specialized… (More)
- Abhinav Sinha, Katie R Hughes, +13 authors Andrew P Waters
- Nature
- 2014
Commitment to and completion of sexual development are essential for malaria parasites (protists of the genus Plasmodium) to be transmitted through mosquitoes. The molecular mechanism(s) responsible… (More)
A Plasmodium falciparum histone deacetylase regulates antigenic variation and gametocyte conversion.
- Bradley Coleman, Kristen M. Skillman, +10 authors Manoj Duraisingh
- Cell host & microbe
- 2014
The asexual forms of the malaria parasite Plasmodium falciparum are adapted for chronic persistence in human red blood cells, continuously evading host immunity using epigenetically regulated… (More)
- Germán Plata, Tzu-Lin Hsiao, Kellen L. Olszewski, Manuel Llinás, Dennis Vitkup
- Molecular systems biology
- 2010
Genome-scale metabolic reconstructions can serve as important tools for hypothesis generation and high-throughput data integration. Here, we present a metabolic network reconstruction and… (More)
- Guangan Hu, Manuel Llinás, Jingguang Li, Peter Rainer Preiser, Zbynek Bozdech
- BMC Bioinformatics
- 2006
The design of long oligonucleotides for spotted DNA microarrays requires detailed attention to ensure their optimal performance in the hybridization process. The main challenge is to select an… (More)