Manuel Joao Amaro

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The capability of hepatitis B virus (HBV) to increase the transcription of the human hepatic inducible nitric oxide synthase (iNOS) by transactivating its promoter has been studied. We have observed by reverse-transcription polymerase chain reaction (RT-PCR) that although the mRNA for the iNOS was almost undetectable in the human hepatoblastoma cell line,(More)
Nitric oxide is a free radical gas molecule which may be implicated in antiviral defense. However, there is no information about its possible role in chronic viral hepatitis B and C. In this study we have analyzed the serum levels of NO2- (as an index of nitric oxide generation) from patients with chronic viral hepatitis B and C and relationship of same(More)
Acute and chronic liver dysfunction is common after allogeneic bone marrow transplantation (BMT). Although toxicity, graft versus-host disease (GVHD), and viral infections are the major causes, etiologic diagnosis is difficult and often remains unknown. We conducted a prospective study to establish the role of the infection with both the hepatitis C virus(More)
The nucleotide sequence of hepatitis GB virus type C (HGBV-C)/hepatitis G virus (HGV) NS3/helicase and 5'-untranslated regions from 23 Spanish patients were analyzed to assign the HGV isolates one of the proposed HGBV-C/HGV genotypes. The analysis of the evolutionary distance frequency showed that the distances among all sequences in NS3/helicase region(More)
Nowadays, organizations to survive competitively they need to be, innovative and efficient. The way the Internet has been expanding along with other technological changes is leading us to a future in which all the objects that surround us will be seamlessly integrated into information networks. The possibility to implement concepts related with the(More)
This paper presents a design and simulation of the functions of a Flight Management System (FMS) in order to follow automatically four-dimensional trajectories. This is achieved by controlling the aircraft airspeed, altitude, heading and vertical speed in order to arrive to the merging point in the specified time. The system receives data from the aircraft(More)
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