Manuel Jesús Bellido Díaz

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BACKGROUND As part of an evaluation of strategies to make inactivated poliovirus vaccine (IPV) affordable for developing countries, we conducted a clinical trial of fractional doses of IPV in Cuba. METHODS We compared the immunogenicity and reactogenicity of fractional-dose IPV (0.1 mL, or 1/5 of a full dose) given intradermally using a needle-free jet(More)
BACKGROUND To reduce the costs of maintaining a poliovirus immunization base in low-income areas, we assessed the extent of priming immune responses after the administration of inactivated poliovirus vaccine (IPV). METHODS We compared the immunogenicity and reactogenicity of a fractional dose of IPV (one fifth of a full dose) administered intradermally(More)
Glycoconjugate vaccines provide effective prophylaxis against bacterial infections. To date, however, no commercial vaccine has been available in which the key carbohydrate antigens are produced synthetically. We describe the large-scale synthesis, pharmaceutical development, and clinical evaluation of a conjugate vaccine composed of a synthetic capsular(More)
INTRODUCTION The World Health Organization recommends that, as part of the new polio endgame, a dose of inactivated poliovirus vaccine (IPV) be introduced by the end of 2015 in all countries using only oral poliovirus vaccine (OPV). Administration of fractional dose (1/5th of full dose) IPV (fIPV) intradermally may reduce costs, but its administration is(More)
In this work, we present a computational behavioralmodel for logic gates called Internode (Internal Node LogicComputational Model) that considers the functionality ofthe gate as well as all the different internal states the gatecan reach. This computational model can be used in logic-leveltools and is valid for any dynamic behavioral model(delay models,(More)
This contribution successfully accomplished the design and implementation of an advanced DSP circuit for direct measurements of electrical network parameters (RMS and real and reactive power) with application to network monitoring and quality assurance. The device is implemented on a mid-range Xilinx Spartan-3 family FPGA and includes an OPE interface so(More)