Manuel J. Ibarra

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The flavonoid quercetin is metabolized into isorhamnetin, tamarixetin, and kaempferol, the vascular effects of which are unknown. In the present study, the effects of quercetin and its metabolites were analyzed on isometric tension in isolated rat thoracic and abdominal aorta, in isolated intact and beta-escin-permeabilized iliac arteries, and on perfusion(More)
The flavonoid quercetin reduces blood pressure and endothelial dysfunction in animal models of hypertension. However, the results concerning the relationship between quercetin and NO present a complex picture. We have analyzed the mechanisms involved in the NO scavenging effects of quercetin and its repercussion on NO bioactivity in vascular smooth muscle.(More)
Isorhamnetin and quercetin produced endothelium-independent vasodilator effects in rat aorta, rat mesenteric arteries, rat portal vein and porcine coronary arteries. The effects of the two flavonoids were similar in arteries stimulated by noradrenaline, KCl, U46619 or phorbol esters but the two flavonoids were more potent in the coronary arteries than in(More)
Chronic oral quercetin exerts antihypertensive effects in spontaneously hypertensive rats (SHR). In the present study, the vasodilator effects of the flavonoid quercetin and its main metabolite isorhamnetin were analysed in isolated thoracic aorta, iliac artery and on the isolated perfused mesenteric resistance vascular bed from SHR and normotensive Wistar(More)
A firefighter Incident Commander (IC) is responsible for organizing, coordinating and making decisions in most urban emergencies, such as fires and car crashes. The lack of supporting information and the limitations of the radio systems push the IC to make decisions with little or no information; therefore his actions tend to be improvisations. This article(More)
Firefighters are responsible for dealing with several types of urban emergencies, such as fires, car crashes and explosions. The participants in an emergency response process require shared information to make effective, on-time decisions, and to coordinate their activities. The information sharing process is currently performed using message exchange(More)
The need to use mobile technology in urban emergency response processes has recently been identified, given the importance of having relevant information to make decisions in these scenarios. The data visualization on small mobile devices, such as PDAs or smartphones, is a critical aspect to make appropriate and on-time decisions. This criticality(More)