Manuel Hoch

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A phase II trial was performed to assess the efficacy and toxicity of the combination mitoxantrone (MXN) and vinorelbine (VNR) as first-line chemotherapy for metastatic breast cancer. Forty-one patients with metastatic disease or local relapse recruited between March 1991 and April 1993 received a first-line chemotherapy treatment consisting in 12 mg/m2(More)
A radioimmunoassay technique using a double antibody procedure for human serum thyroglobulin (HTg) is described. Only antigen labeling with iodine-125 is performed extemporaneously, the other reagents being purchased commercially. Quality criteria were: sensitivity (2 μg/l), interassay reproducibility (coefficient of variance, C.V.=11%) and specificity are(More)
Die Evolution des Internets in Richtung Web 2.0 zeigt einen klaren Trend hin zur Multi-User Interaction. Neben dem Einsatz neuer Technologien baut das Web 2.0 auf kollektives Wissen, (Wisdom of the Crowds). Das Social Web ermöglicht einer Vielzahl von Nutzern, aktiv zur gemeinsamen Schaffung von Inhalten und derer Vernetzung beizutragen. Die Site an sich(More)
A radioimmunoassay technique using a double antibody procedure for human serum thyroglobulin (HTg) is described. Only antigen labeling with iodine-125 is performed extemporaneously, the other reagents being purchased commercially. Quality criteria were: sensitivity (2 microgram/l), interassay reproducibility (coefficient of variance, C.V. = 11%) and(More)
To evaluate the utility of bone scans for the follow-up of patients with small breast cancers (T less than or equal to 3 cm), the files for 133 patients whose disease was diagnosed between Jan. 1, 1979 and Dec. 31, 1980 were reviewed. At initial presentation, two of these patients already had bone metastases. During their disease course, 30 patients(More)
BACKGROUND Epidermolysis bullosa acquisita (EBA) is a rare, potentially devastating autoimmune disease of the skin. IgG autoantibodies directed against type VII collagen (Col7), the major component of anchoring fibrils, induce skin fragility leading to cutaneous and mucocutaneous blister formation, which is mostly of a scarring phenotype. Thus, powerful and(More)
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