Manuel Delgado

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MicroRNA have been demonstrated to be deregulated in multiple myeloma. We have previously reported that miR-214 is down-regulated in multiple myeloma compared to in normal plasma cells. The functional role of miR-214 in myeloma pathogenesis was explored by transfecting myeloma cell lines with synthetic microRNA followed by gene expression profiling.(More)
Charged cyclometalated (C(^)N) iridium(III) complexes with carbene-based ancillary ligands are a promising family of deep-blue phosphorescent compounds. Their emission properties are controlled primarily by the main C(^)N ligands, in contrast to the classical design of charged complexes where N(^)N ancillary ligands with low-energy π* orbitals, such as(More)
Use of diazoxide in management of severe postprandial hypoglycemia in patient after Roux-en-Y gastric bypass Abel Gonzalez-Gonzalez, Ph.D., M.D.*, Manuel Delgado, M.D., Maria D. Fraga-Fuentes, Pharm.D. Department of Endocrinology and Nutrition, General Hospital of Ciudad Real, Ciudad Real, Spain Department of Pharmacy, General Hospital La Mancha-Centro,(More)
An optimal harvesting problem with a concave nonquadratic cost functional and a diffusive degenerate elliptic logistic state equation type is investigated. Under certain assumptions, we prove the existence and uniqueness of an optimal control. A characterization of the optimal control via the optimality system is also derived, which leads to approximating(More)
Despite the advantage observed with novel drugs such as bortezomib, thalidomide, or lenalidomide, multiple myeloma (MM) remains incurable and there is a clear need for new drugs or combinations based on the pathogenetic mechanism of MM. One of the proposed mechanisms in MM pathogenesis is the involvement of kinase molecules in the growth and survival of(More)
OBJECTIVES Direct-acting antiviral agents (DAAs) have provided an ultimate treatment duration of 12 weeks for most hepatitis C virus (HCV)-infected patients. The opportunity to reduce treatment duration to 6 or 8 weeks is being evaluated. Here, the HCV viral dynamics at short times during HCV therapies and its implications for monitoring and optimizing(More)