Manuel Campos

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The disruption of the circadian system in humans has been associated with the development of chronic illnesses and the worsening of pre-existing pathologies. Therefore, the assessment of human circadian system function under free living conditions using non-invasive techniques needs further research. Traditionally, overt rhythms such as activity and body(More)
In this paper, we propose a new algorithm, called ClaSP for mining frequent closed sequential patterns in temporal transaction data. Our algorithm uses several efficient search space pruning methods together with a vertical database layout. Experiments on both synthetic and real datasets show that ClaSP outperforms currently well known state of the art(More)
Sequential pattern mining algorithms using a vertical representation are the most efficient for mining sequential patterns in dense or long sequences, and have excellent overall performance. The vertical representation allows generating patterns and calculating their supports without performing costly database scans. However, a crucial performance(More)
In the Intensive Care Unit (ICU) domain, temporal evolution of diseases and patients’ contextual information are critical pieces of knowledge that must be considered in the design of a diagnosis task. The uncertainty inherent in the description of temporal information associated to diseases requires a temporal representation and reasoning framework. This(More)
Medical knowledge representation and management is concerned with how to organise the often vague clinical experience of medical staff required for computable models. However, few knowledge management and acquisition tools have entered routine use, since such tools are not perceived by physicians as part of the clinical information process. An attempt to(More)
Immune memory is the foundation of the practise of vaccination. Research on the molecular and cellular events leading to generation and development of memory T and B lymphocytes explain why there are heightened secondary immune responses after an initial encounter with antigen. In this review, we discuss how clonal expansion, targeted tissue localisation,(More)
OBJECTIVE The aim of this work is to provide a theoretical framework which is sufficiently expressive to describe temporal evolution of diseases, and also to propose a diagnostic process for building explanations of patient's observed temporal evolution based on these disease descriptions. BACKGROUND Model-based diagnosis (MBD) tackles the problem of(More)