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  • Manuel Campos, Ivan V. Surovtsev, Setsu Kato, Ahmad Paintdakhi, Bruno Beltran, Sarah E. Ebmeier +1 other
  • 2014
Cell size control is an intrinsic feature of the cell cycle. In bacteria, cell growth and division are thought to be coupled through a cell size threshold. Here, we provide direct experimental evidence disproving the critical size paradigm. Instead, we show through single-cell microscopy and modeling that the evolutionarily distant bacteria Escherichia coli(More)
In the Intensive Care Unit (ICU) domain, temporal evolution of diseases and patients' contextual information are critical pieces of knowledge that must be considered in the design of a diagnosis task. The uncertainty inherent in the description of temporal information associated to diseases requires a temporal representation and reasoning framework. This(More)
OBJECTIVE The aim of this work is to provide a theoretical framework which is sufficiently expressive to describe temporal evolution of diseases, and also to propose a diagnostic process for building explanations of patient's observed temporal evolution based on these disease descriptions. BACKGROUND Model-based diagnosis (MBD) tackles the problem of(More)
Sequential pattern mining algorithms using a vertical representation are the most efficient for mining sequential patterns in dense or long sequences, and have excellent overall performance. The vertical representation allows generating patterns and calculating their supports without performing costly database scans. However, a crucial performance(More)
In this paper, we propose a new algorithm, called ClaSP for mining frequent closed sequential patterns in temporal transaction data. Our algorithm uses several efficient search space pruning methods together with a vertical database layout. Experiments on both synthetic and real datasets show that ClaSP outperforms currently well known state of the art(More)
In Gram-negative bacteria, type II secretion systems (T2SS) assemble inner membrane proteins of the major pseudopilin PulG (GspG) family into periplasmic filaments, which could drive protein secretion in a piston-like manner. Three minor pseudopilins PulI, PulJ and PulK are essential for protein secretion in the Klebsiella oxytoca T2SS, but their molecular(More)
The disruption of the circadian system in humans has been associated with the development of chronic illnesses and the worsening of pre-existing pathologies. Therefore, the assessment of human circadian system function under free living conditions using non-invasive techniques needs further research. Traditionally, overt rhythms such as activity and body(More)