Manuel Bernal-Sprekelsen

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The incidence of head and neck squamous cell carcinoma (HNSCC) has been gradually increasing over the last three decades. Recent data have now attributed a viral aetiology to a subset of head and neck cancers. Several studies indicate that oral human papillomavirus (HPV) infection is likely to be sexually acquired. The dominance of HPV 16 in HPV+ HNSCC is(More)
CONCLUSIONS These results demonstrate that functional magnetic resonance imaging (fMRI) is an optimal tool to investigate the auditory cortex. The study suggests that there is a medio-lateral gradient of responsiveness to high frequencies medially and low frequencies laterally. The contralateral auditory cortex is more responsive than the ipsilateral cortex(More)
Omalizumab, a humanised monoclonal anti-immunoglobulin E (IgE) antibody, is indicated as adjuvant treatment in refractory allergic severe asthma. 1 In both chronic rhinosinusitis (CRS) with nasal polyps (NP) and allergic rhinitis, IgE is increased in mucosal tissue and frequently in serum. The role of omalizumab has been clearly established in allergic(More)
INTRODUCTION Sudden sensorineural hearing loss (SSHL) has been proposed as a symptom of underlying vascular problems. The purpose of this work is to evaluate the genetic and acquired risk factors. METHODS Ninety-nine patients were tested for the presence of common polymorphisms related to thrombophilia (prothrombin and factor V Leiden) in order to assess(More)
OBJECTIVES To investigate olfaction in general population, prevalence of olfactory dysfunction and related risk factors. DESIGN Cross-sectional population-based survey, distributing four microencapsulated odorants (rose, banana, musk and gas) and two self-administered questionnaires (odour description; epidemiology/health status). SETTING The survey was(More)
BACKGROUND The main causative process in idiopathic sudden sensorineural hearing loss (iSSNHL) has yet to be explained or demonstrated. The clinical picture supports vascular involvement, but obvious limitations of inner ear study make this difficult to corroborate. OBJECTIVES To determine the role of thrombophilic genetic variants that may affect(More)
BACKGROUND Endoscopic skull base surgery is now the preferred treatment option to remove skull base tumors. OBJECTIVE To evaluate the patient's sense of smell and mucociliary clearance time (MCT) after skull base surgery. METHODS Patients with pituitary adenoma underwent a transnasal transsphenoidal endoscopic approach (TTEA group, n = 36), whereas(More)
OBJECTIVE To evaluate anatomical and functional results using titanium prostheses in cartilage palisade tympanoplasties. STUDY DESIGN Retrospective clinical study. Data were collected from patients' charts and clinical review. SETTING Tertiary referral center. INTERVENTION Cartilage tympanoplasty with titanium total ossicular replacement prosthesis(More)
OBJECTIVE To evaluate the long-term anatomic and functional results after partial and total autologous cartilage palisade type III tympanoplasties to assess the efficacy of cartilage palisades in preventing recurrent cholesteatoma. STUDY DESIGN Retrospective data bank and patient review. SETTING Tertiary referral center. PATIENTS The study population(More)
INTRODUCTION We present our experience in the reconstruction of these leaks depending on their size and location. MATERIAL AND METHODS Fifty-four patients who underwent advanced skull base surgery (large defects, >20 mm) and 62 patients with CSF leaks of different origin (small, 2-10 mm, and midsize, 11-20 mm, defects) were included in the retrospective(More)