Manuel Barreiro-de-Acosta

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Biological drugs or biopharmaceutical products, manufactured with or from living organisms using biotechnology, have represented a therapeutic revolution for the control of inflammatory bowel disease (IBD). At present, in this indication and in our country, only two biological are approved, infliximab (IFX) and adalimumab (ADA), both of them monoclonal(More)
Crohn's disease (CD) is a genetically complex disease in which both genetic susceptibility and environmental factors play key roles in the development of the disorder. NOD2/CARD15 mutations are associated with CD. NOD2 encodes for a protein that is an intracellular receptor for a bacterial product (muramyl dipeptide), though the exact functional(More)
BACKGROUND AND AIMS The aims of this study were to evaluate the frequency of entero-urinary fistulas in a cohort of Crohn's disease (CD) patients and to analyse the outcomes of medical and surgical therapy. METHODS This multicentre retrospective study included all CD patients with entero-urinary fistulas diagnosed by the presence of clinical symptoms and(More)
BACKGROUND AND AIMS Crohn's disease (CD) is commonly associated with inflammatory processes located in organs and systems others than the gut, which are known as extraintestinal manifestations (EIM) of the disease. The aim of this study was to assess the effectiveness of adalimumab (ADA) for the treatment of EIM in patients with CD. METHODS forty two(More)
Down's syndrome (DS) is a genetic disease that has been associated with several immune and autoimmune diseases, including digestive and liver diseases, like celiac disease, autoimmune chronic hepatitis and sclerosing cholangitis.Despite in inflammatory bowel disease (IBD) pathogenesis, genetics and immune mechanism play an important role, the association(More)
A 41-year-old man with a past history of ulcerative colitis was referred to our rheumatology unit because of bilateral gonalgia. Thirteen years before, when he was diagnosed as having IBD, colonoscopy showed active and extensive ulcerative pancolitis (E3 according with Montreal classification); biopsies of the mucosa confirmed the diagnosis.(More)