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In situ hybridization and Northern blots were used to study expression of mRNAs for members of the nerve growth factor family in the rat brain following an excitatory stimulus. One hour after a unilateral needle insertion or saline injection into the dorsal hippocampus, the level of brain-derived neurotrophic factor (BDNF) mRNA increased markedly in(More)
The aim of domain engineering process is to define and realise the commonality and variability of a Software Product Line. In the context of a family of models, spotting the commonalities and differences may become cumbersome and error prone as the number of models and its complexity increases. This work presents an approach to automate the formalization of(More)
Microdialysis technique was used to study the effects of both acute and repeated oral administration of calcium-channel blockers (flunarizine, cinnarizine, verapamil, nifedipine and nicardipine) in dopaminergic function in rat brain and to compare them to the effects of haloperidol. Acute flunarizine, nicardipine or haloperidol increased extracellular(More)
Clone-and-Own (CAO) is a common practice in families of software products consisting of reusing code from methods in legacy products in new developments. In industrial scenarios, CAO consumes high amounts of time and effort without guaranteeing good results. We propose a novel approach, Computer Assisted CAO (CACAO), that given the natural language(More)
1. The involvement of presynaptic 5-hydroxytryptamine1A (5-HT1A) autoreceptors in the anxiolytic-like properties of lesopitron (E-4424) (2-(4-[4-(4-chloro-1-pyrazolyl)butyl]-1- piperazinyl)pyrimidine) was studied. Brain microdialysis was used to examine the effect of the drug on the release of 5-hydroxytryptamine (5-HT) and its metabolite(More)
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