Manuel Aldegunde

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This study examines the age-associated changes in noradrenaline (NA), dopamine (DA), 3,4-dihydroxyphenyl-acetic acid (DOPAC), serotonin (5-HT) and 5-hydroxy-3-indoleacetic acid (5-HIAA) in different brain areas of rats. DA and DOPAC concentrations in striatum increased at third month of age, remaining without significant variations until 12th month of age,(More)
This review focuses on recent research on the metabolic function of fish brain. Fish brain is isolated from the systemic circulation by a blood-brain barrier that allows the transport of glucose, monocarboxylates and amino acids. The limited information available in fishes suggests that oxidation of exogenous glucose and oxidative phosphorylation provide(More)
In this paper, we review and extend recent work on the effect of random discrete dopants on the statistical variability in gate-all-around silicon nanowire transistors. The electron transport is described using the nonequilibrium Green's function formalism. Full 3-D real-space and coupled-mode-space repre sentations are used. Two different cross sections(More)
Lampreys are suitable animal models for studying the evolution of the vertebrate nervous system because they belong to the earliest group of extant vertebrates, the agnathans. The general organization of the serotonergic central nervous system is well known in lampreys, but information about its peripheral organization is lacking. In the present study,(More)
The levels of glycogen, lactate, acetoacetate and β-hydroxybutyrate in brain as well as glycogen and lactate levels in liver, and glucose levels in plasma were evaluated in rainbow trout, Oncorhynchus mykiss, injected with ethanol/saline (5/95; v/v) alone (controls) or containing melatonin at three different doses 0.25, 0.5 and 1 mg kg-1. The results(More)
The effects of central (intracerebroventricular, 9 μg fish−1) and peripheral (intraperitoneal, 4 mg kg−1) administration of bovine insulin, as well as the effect of hyperglycemia (oral administration of 1 g glucose fish−1) and brain glucodeprivation (intracerebroventricular administration of 2-deoxy-D-glucose) on food intake and levels of brain(More)
A 3-D quantum-corrected drift-diffusion (DD) simulation study of three sources of statistical variability, including discrete random dopants (RDs), line-edge roughness (LER), and metal gate workfunction (MGW) was performed for a 14-nm gate length In0.53Ga0.47As FinFET in the subthreshold region using Fermi-Dirac statistics. This paper has been done at both(More)
An efficient implementation of the density-gradient (DG) approach for the finite element and finite difference methods and its application in drift-diffusion (D-D) simulations is described in detail. The new, second-order differential (SOD) scheme is compatible with relatively coarse grids even for large density variations thus applicable to device(More)
In this paper, we investigate the gate misalignment effects in a 10-nm double-gate silicon-on-insulator MOSFET transistor with a 2-D Monte Carlo simulator. Quantum effects, which are of special relevance in such devices, are taken into account by using the multivalley effective conduction-band-edge method. Different gate misalignment configurations have(More)
Brain glycogen is depleted when used as an emergency energy substrate. In mammals, brain glycogen levels rebound to higher than normal levels after a hypoglycemic episode and a few hours after refeeding or administration of glucose. This phenomenon is called glycogen supercompensation. However, this mechanism has not been investigated in lower vertebrates.(More)