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By using a rat seizure model, a comparison of the antiseizure activity of 12 dihydropyridine calcium channel antagonists (administered i.c.v.) to their binding affinities for the neuronal site known to regulate L-type calcium channels was made. For these dihydropyridine calcium channel antagonists a correlation between physiologic activity and binding… (More)
We interpret the reciprocation process in K[[x]] as a fixed point problem related to contractive functions for certain adequate ultrametric spaces. This allows us to give a dynamical interpretation of certain arithmetical triangles introduced herein. Later we recognize, as a special case of our construction, the so called Riordan group which is a device… (More)
The dihydropyridine calcium channel antagonist, nimodipine has antiepileptic and anticonvulsive properties that are thought to be mediated through neuronal calcium channel blockade. The dihydropyridine binding site can be positively and negatively allosterically regulated by the benzothiazepines and the phenylalkylamines/piperazines, respectively. We… (More)
We use upper semifinite hyperspaces of compacta to describe ε-connectedness and to compute homology from finite approximations. We find another connection between ε-connectedness and the so called Shape Theory. We construct a geodesically complete R-tree, by means of ε-components at different resolutions, whose behavior at infinite captures the topolog-ical… (More)
Recently, the concept of the complementary array of a Riordan array (or recursive matrix) has been introduced. Here we generalize the concept and distinguish between dual and complementary arrays. We show a number of properties of these arrays, how they are computed and their relation with inversion. Finally, we use them to find explicit formulas for the… (More)
Abbreviated title: " Self-inverse sequences and involutions " .
The release of [3H]purines was investigated in a crude mitochondrial fraction (P2 fraction) from rat brain cortex pre-loaded with [3H]adenosine for 30 sec at 37 degrees C in vitro. Potassium, veratridine and glutamate were used as depolarizing agents to evoke the release of [3H]purines. Ca2+ removal, the addition of EGTA, and treatment with organic or… (More)