Manuel A . Fernández - Rodríguez

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Previous studies have shown that neointima formation and adventitial remodeling play an important role in the enlargement of collateral vessels (CVs) during coronary arteriogenesis in the dog heart. In this study, we investigated the importance of remodeling of the tunica media in the same model. Basal membrane (BM), contractile and cytoskeletal components(More)
Apoptosis, one of the major forms of cell death, has been implicated in different cardiovascular diseases. In this paper we review many of the different studies that have been performed to address the occurrence of apoptotic cell death associated with myocardial infarction. A definitive differentiation between apoptosis and other forms of cell death is(More)
In this study we tested our previous hypothesis that ischemia is a multifactorial injurious event involving all components of the myocyte simultaneously. This hypothesis was based on ultrastructural findings and was now tested again by protein analysis of sarcolemmal structural proteins and of markers of transcriptional and translational activities. This(More)
In this short review article we discuss the many uncertainties with the estimation of the relevance of data on the rate of apoptotic cell death in the myocardium. 1. The time course and duration of the apoptotic cascade is still almost completely unknown, in cardiac tissue as well as in myocytes in culture. 2. The mode of removal of dead cells from their(More)
Null alleles can occur with any PCR-based STR typing system. They generally are due to deletions within the target region or primer binding sites or by primer binding site mutations that destabilize hybridization of at least one of the primers flanking the target region. Although not common, null types were detected at the DYS448 locus in seven out of 1,005(More)
Template for SYNLETT and SYNTHESIS © Thieme Stuttgart · New York 2015-01-22 page 1 of 13 Abstract: A new access to benzofulvenes bearing an indol-3-yl substituent at C-2 has been developed. Treatment of 3propargylindoles possessing an additional hydroxyl group at the other propargylic position with a cationic gold(I) complex triggers a tandem 1,2-indole(More)
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