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Computational neuroscience combines theory and experiment to shed light on the principles and mechanisms of neural computation. This approach has been highly fruitful in the ongoing effort to understand velocity computation by the primate visual system. This Review describes the success of spatiotemporal-energy models in representing local-velocity(More)
We analyze volume flexibility — the ability to produce above/below the installed capacity for a product — under endogenous pricing in a two-product setting. We discover that the value of volume flexibility is a function of demand correlation between products, an outcome which cannot be explained by classical risk-pooling arguments. Furthermore, while the(More)
This paper studies the impact of competition on a firm's choice of technology (product-flexible or product-dedicated) and capacity investment decisions. Specifically, we model two firms competing with each other in two markets characterized by price-dependent and uncertain demand. The firms make three decisions in the following sequence: choice of(More)
The importance of material flow management for a profit-maximizing firm has been well-articulated in the supply chain literature. We demonstrate in our analytical model that a firm must also actively manage information flows within the supply chain, which translates to controlling what it knows, as well as what its competitors and suppliers know. In our(More)
Aerobic glycolysis (AG; i.e., nonoxidative metabolism of glucose despite the presence of abundant oxygen) accounts for 10%-12% of glucose used by the adult human brain. AG varies regionally in the resting state. Brain AG may support synaptic growth and remodeling; however, data supporting this hypothesis are sparse. Here, we report on investigations on the(More)
When blind people touch Braille characters, blood flow increases in visual areas, leading to speculation that visual circuitry assists tactile discrimination in the blind. We tested this hypothesis in a functional magnetic resonance imaging study designed to reveal activation appropriate to the nature of tactile stimulation. In late-blind individuals,(More)
Postnatal cortical synaptic development is characterized by stages of exuberant growth, pruning, and stabilization during adulthood. How gene expression orchestrates these stages of synaptic development is poorly understood. Here we report that synaptic growth-related gene expression alone does not determine cortical synaptic density changes across the(More)
PURPOSE OF REVIEW To review recent advances in understanding supraaortic arterial dissections and their diagnosis and management. RECENT FINDINGS Dissection of the supraaortic arteries, including the extracranial carotid and vertebral arteries and intracranial arteries, is increasingly identified as an important cause of stroke and subarachnoid(More)
Product launch – an event when a new product debuts for production in a plant – is an important phase in product development. But launches disrupt manufacturing operations resulting in productivity losses. Using data from North-American automotive plants from years 1999-2007, we estimate that a product launch entails an average productivity loss of 12-15%(More)