Manon D Schulz

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The Rockefeller University Press $30.00 J. Exp. Med. Vol. 207 No. 12 2621-2630 www.jem.org/cgi/doi/10.1084/jem.20100864 2621 NF-B plays an important role in the regulation of diverse biological processes such as development, immune and inflammatory responses, and apoptosis (Baldwin, 1996; Gilmore, 2006; Ghosh and Hayden, 2008). Through its ubiquitous(More)
Inhibitor of κB (IκB) β (IκBβ) represents one of the major primary regulators of NF-κB in mammals. In contrast to the defined regulatory interplay between NF-κB and IκBα, much less is known about the biological function of IκBβ. To elucidate the physiological role of IκBβ in NF-κB signaling in vivo, we generated IκBβ-deficient mice. These animals proved to(More)
Several features common to a Western lifestyle, including obesity and low levels of physical activity, are known risk factors for gastrointestinal cancers. There is substantial evidence suggesting that diet markedly affects the composition of the intestinal microbiota. Moreover, there is now unequivocal evidence linking dysbiosis to cancer development.(More)
Obesity is associated with increased risk for developing pancreatic cancer, and it is suggested that insulin resistance provides the missing link. Here we demonstrate that under the context of genetic susceptibility, a high fat diet (HFD) predisposes mice with oncogenic K-ras activation to accelerated pancreatic intraepithelial neoplasm (PanIN) development.(More)
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