Manolis Tsiknakis

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The "Oncosimulator" is at the same time a concept of multilevel integrative cancer and (treatment affected) normal tissue biology, an algorithmic construct and a software tool which aims at supporting the clinician in the process of optimizing cancer treatment on the patient individualized basis. Additionally it is a platform for better understanding and(More)
OBJECTIVE The paper presents an application of the "Fit between Individuals, Task and Technology" (FITT) framework to analyze the socio-organizational-technical factors that influence IT adoption in the healthcare domain. METHOD The FITT framework was employed as the theoretical instrument for a retrospective analysis of a 15-year effort in implementing(More)
Information extraction from microarrays has not yet been widely used in diagnostic or prognostic decision-support systems, due to the diversity of results produced by the available techniques, their instability on different data sets and the inability to relate statistical significance with biological relevance. Thus, there is an urgent need to address the(More)
For the last five years, a system for the management and coordination of pre-hospital health emergency has been in regular use at the Emergency Coordination Centre of Heraklion, as part of HYGEIAnet, the Regional Health Information Network of Crete. Approximately 20,000 emergency episodes per year are currently being logged in the system. The need for(More)
This paper reports on original results of the Advancing Clinico-Genomic Trials on Cancer integrated project focusing on the design and development of a European biomedical grid infrastructure in support of multicentric, postgenomic clinical trials (CTs) on cancer. Postgenomic CTs use multilevel clinical and genomic data and advanced computational analysis(More)
Advances in information technology in the past decade have resulted in a proliferation of clinical information systems dedicated to individual user groups and clinical functional areas. This, in turn, has led to the need for hospital-wide management and integration of information, and has triggered major efforts towards the development of integrated(More)
The term electronic health record (EHR) refers to the complete set of information that resides in electronic form and is related to the past, present, and future health status or health care provided to a subject of care. The primary purpose of EHRs is the documentation, retrieval, transmission, linking, and processing of multimedia information to(More)
Pre-hospital emergency care plays a vital role in saving human lives making it an important part of the health care sector. Efficiency and effectiveness of operations is crucial especially when dealing with life-threatening situations that require immediate and specialised response. In Crete, the National Centre for Emergency Care has established several(More)
HEARTFAID is a research and development project aimed at devising, developing and validating an innovative knowledge based platform of services, able to improve early diagnosis and to make more effective the medical-clinical management of heart diseases within elderly population. Chronic Heart Failure is one of the most remarkable health problems for(More)