Manoj Pillai

Learn More
miRNAs regulate the expression of genes in both normal physiology and disease. While miRNAs have been demonstrated to play a pivotal role in aspects of cancer biology, these reports have generally focused on the regulation of single genes. Such single-gene approaches have significant limitations, relying on miRNA expression levels and heuristic predictions(More)
When transgenic mice are created by microinjection of DNA into the pronucleus, the sites of DNA integration into the mouse genome cannot be predicted. Most methods based on polymerase chain reaction (PCR) that have been used for determining the integration site of foreign DNA into a genome require specific reagents and/or complicated manipulations making(More)
Stromal Derived Factor 1 (SDF1 or CXCL12), is a chemokine known to be critical for the migration of cells in several tissue systems including the homing of the hematopoietic stem cell (HSC) to its niche in the bone marrow. A comparative analysis of miRNA expression profiles of two stromal cell lines, distinguishable by function and by CXCL12 expression(More)
Regulation of hematopoietic stem cell proliferation, lineage commitment, and differentiation in adult vertebrates requires extrinsic signals provided by cells in the marrow microenvironment (ME) located within the bone marrow. Both secreted and cell-surface bound factors critical to this regulation have been identified, yet control of their expression by(More)
In this paper we present an eecient design for message passing over a reeective memory network. First, we consider the attributes of reeec-tive memory communication networks and the requirements to eeciently build message-passing functional-ity on these networks. We then introduce the Bill-Board Protocol, a lock-free protocol which provides low-latency(More)
Striped file systems such as the Parallel Virtual File System (PVFS) deliver high-bandwidth I/O to applications running on clusters. An open problem of existing striped file systems is how to provide efficient data redundancy to decrease their vulnerability to disk failures. In this paper we describe CSAR, a version of PVFS augmented with a novel redundancy(More)
Recurrent mutations in core splicing factors have been reported in several clonal disorders, including cancers. Mutations in SF3B1, a component of the U2 splicing complex, are the most common. SF3B1 mutations are associated with aberrant pre-mRNA splicing using cryptic 3' splice sites (3'SSs), but the mechanism of their selection is not clear. To understand(More)
Clusters of workstations have emerged as a popular platform for parallel and distributed computing. Commodity high speed networks which are used to connect workstation clusters provide high bandwidth, but also have high latency. SCRAMNet is an extremely low latency replicated non-coherent shared memory network, so far used only for real-time applications.(More)
Marrow stromal cells (MSCs, also termed mesenchymal stem cells) have been proposed as a promising cellular therapy for tissue injury including radiation-induced marrow failure, but evidence for a direct effect is lacking. To assess the effects of MSCs on survival after lethal irradiation, we infused syngeneic MSCs (either as immortalized MSCs clones or(More)
Regulatory molecules produced by stromal cells are often membrane bound until cleaved by matrix metalloproteinases (MMPs); cleavage can either activate or inactivate regulatory functions. We report here that marrow stromal cells induce the expression of MMP-9 in monocytes. Induction was contact independent and could be reproduced with recombinant(More)