Mano J. Thubrikar

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BACKGROUND The study was intended to investigate the reason why congenitally bicuspid valves (CBAVs), which may function hemodynamically and clinically well, have a high early failure rate. METHODS Observations were made on cryopreserved, then thawed human aortic roots containing CBAVs. Valvular function was studied in the left heart simulator using(More)
BACKGROUND The downward movement of the aortic root during the cardiac cycle may be responsible for producing the circumferential tear observed in aortic dissections. METHODS AND RESULTS Contrast injections were investigated in 40 cardiac patients, and a finite element model of the aortic root, arch, and branches of the arch was built to assess the(More)
There is a need to understand why and where the abdominal aortic aneurysm may rupture. Our goal therefore is to investigate whether the mechanical properties are different in different regions of the aneurysm. Aorta samples from five freshly excised whole aneurysms, > or = 5 cm in diameter, from five patients, average age 71 +/- 10 years, were subjected to(More)
In aortic dissection intimal tear develops in a transverse direction. Since dissection is associated with the aneurysm of the aorta, its mechanism was investigated by analysing the pressure induced wall stress as a function of 'growth' of the aneurysm. The stresses were determined using a finite element analysis where the aorta was modelled as an isotropic,(More)
Aortic valve leaflets undergo extraordinary flexion due to the complete reversal of their curvature during billions of cardiac cycles. The flexion stresses in the leaflet depend on its elastic modulus which we investigated in vivo and in vitro. In six dogs, we placed radiopaque markers on an aortic leaflet. Leaflet length was calculated from the marker(More)
To estimate when an abdominal aortic aneurysm (AAA) may rupture, it is necessary to understand the forces responsible for this event. We investigated the wall stresses in an AAA in a clinical model. Using CT scans of the AAA, the diameter and wall thickness were measured and the model of the aneurysm was created. The wall stresses were determined using a(More)
Two hundred twenty-one aortic cusps from 96 patients who underwent aortic valve replacement were examined. Of all the cusps that showed any calcific deposits, 87% had calcific deposits in 1 of 2 specific patterns: a coaptation pattern, where calcific deposits occurred along the line of cusp coaptation, and a radial pattern, where calcific deposits occurred(More)
We present the hypothesis that high wall stress and accompanying stretch, particularly that caused by arterial pressure, are the primary factors responsible for the topography of atherosclerotic lesions. In our view the pattern in the localization of atherosclerotic lesions indicates that the artery behaves as both a pressure vessel and a conduit of blood(More)
The design parameters of the natural aortic valve in vivo were not known, which may explain why various bioprosthetic valves have been designed differently. The design of the aortic valve was studied in vivo by placing radiopaque markers in the valve. The marker movement revealed that, during a cardiac cycle, the design parameters of the valve were changing(More)
OBJECTIVE We propose that the aortic root motion plays an important role in aortic dissection. METHODS AND RESULTS A finite element model of the aortic root, arch and branches of the arch was built to assess the influence of aortic root displacement and pressure on the aortic wall stress. The largest stress increase due to aortic root displacement was(More)