Manman Zhang

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The orthologous penR and pntR genes from the pentalenolactone biosynthetic gene clusters of Streptomyces exfoliatus UC5319 and S. arenae TÜ469, respectively, were predicted to encode MarR/SlyA family transcriptional regulators, responsible for regulation of the biosynthesis of the sesquiterpenoid antibiotic pentalenolactone. The intrinsic target DNA(More)
The EC numbers represent enzymes and enzyme genes (genomic information), but they are also utilized as identifiers of enzymatic reactions (chemical information). In the present work (ECAssigner), our newly proposed reaction difference fingerprints (RDF) are applied to assign EC numbers to enzymatic reactions. The fingerprints of reactant molecules minus the(More)
Bacterial transporters mediate the exchanges between intracellular and extracellular environments. Modification of transport route could be applied to speed up the metabolic reactions and promote the production of aimed compounds. Herein, lysine 2-monooxygenase (DavB) and δ-aminovaleramidase (DavA) were co-expressed in Escherichia coli BL21(DE3) to produce(More)
Department of Chemistry, Box H, Brown University, Providence, Rhode Island 02912-9108, 5 United States 6 The Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Ministry of 7 Education), Wuhan University, Wuhan, Hubei Province, 430071, China 8 Laboratory of Microbial Engineering, Kitasato Institute for Life Sciences, Kitasato University, 9(More)
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