Manjusha Nair

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In this paper, we model function magnetic resonance imaging signals generated by neural activity (fMRI). fMRI measures changes in metabolic oxygen in blood in brain circuits based on changes in biophysical factors like concentration of total cerebral blood flow, oxy-hemoglobin and deoxy-hemoglobin content. A modified version of the Windkessel model by(More)
Understanding functional role of spike bursts in the brain circuits is vital in analyzing coding of sensory information. Information coding in neurons or brain cells happen as spikes or action potentials and excitatory post-synaptic potentials (EPSPs). Information transmission at the Mossy fiber- Granule cell synaptic relay is crucial to understand(More)
Methods originally developed for communication systems are widely used in computational neuroscience to understand the information representation and processing performed by neurons and neural circuits in the brain. Information theoretic quantities Entropy and Mutual Information (MI) have been used in neuroscience as a metric to estimate the efficiency of(More)
Human brain communicates information by means of electro-chemical reactions and processes it in a parallel, distributed manner. Computational models of neurons at different levels of details are used in order to make predictions for physiological dysfunctions. Advances in the field of brain simulations and brain computer interfaces have increased the(More)
Basal ganglia and cerebellum have been implicated in critical roles related to control of voluntary motor movements for action selection and cognition. Basal ganglia primarily receive inputs from cortical areas as well as thalamic regions, and their functional architecture is parallel in nature which link several brain regions like cortex and thalamus.(More)
One of the main challenges in computational modeling of neurons is to reproduce the realistic behaviour of the neurons of the brain under different behavioural conditions. Fitting electrophysiological data to computational models is required to validate model function and test predictions. Various tools and algorithms exist to fit the spike train recorded(More)
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