Manjunatha K. Nanjappa

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Traumatic brain injury (TBI) is an important and costly medical problem for which no clinically proven treatment currently exists. Studies in rodents and humans have shown beneficial effects of progesterone (P4) on both mortality and functional outcomes following TBI. Neuroprotective effects of P4 in TBI likely involve the classical nuclear progesterone(More)
There have been significant breakthroughs over the past decade in the development and use of pluripotent stem cells as a potential source of cells for applications in regenerative medicine. It is likely that this methodology will begin to play an important role in human clinical medicine in the years to come. This review describes the plasticity of one type(More)
M eiosis, the process by which the ovary and testis produce haploid gametes from initially diploid cells, is essential for sexual reproduction in mammals. This process, initially described in the late 19 th and early 20 th century using model organisms such as sea urchins, worms and fruit flies, continues to attract extensive interest from reproductive(More)
How the primordial germ cell (PGC) lineage, which eventually gives rise to spermatozoa in males and oocytes in females, is established in the developing mammalian embryo has been a critical topic in both developmental and reproductive biology for many years. There have been significant breakthroughs over the past two decades in establishing both the source(More)
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