Manjunath Hegde

Learn More
To utilize biofilms for chemical transformations in biorefineries they need to be controlled and replaced. Previously, we engineered the global regulator Hha and cyclic diguanylate-binding BdcA to create proteins that enable biofilm dispersal. Here we report a biofilm circuit that utilizes these two dispersal proteins along with a population-driven(More)
Although the process of drug development requires efficacy and toxicity testing in animals prior to human testing, animal models have limited ability to accurately predict human responses to xenobiotics and other insults. Societal pressures are also focusing on reduction of and, ultimately, replacement of animal testing. However, a variety of in vitro(More)
In this study we aimed to determine the soft tissue norms for the North Indian population based on the laymen perception of facial esthetics and to test the hypothesis that there are racial differences in cephalometric measurement between North Indians and White Americans norms. Two sets (Facial frontal and profile photographs) of 170 standardized facial(More)
Pseudomonas aeruginosa is becoming recognized as an important pathogen in the gastrointestinal (GI) tract. Here we demonstrate that adenosine, derived from hydrolysis of ATP from the eucaryotic host, is a potent interkingdom signal in the GI tract for this pathogen. The addition of adenosine nearly abolished P. aeruginosa biofilm formation and abolished(More)
Automatic construction of knowledge graphs (KGs) from unstructured text has received considerable attention in recent research, resulting in the construction of several KGs with millions of entities (nodes) and facts (edges) among them. Unfortunately, such KGs tend to be severely sparse in terms of number of facts known for a given entity , i.e., have low(More)
The efficacy of the Herbst appliance in a normalizing sagittal relationship in patients with a Class II malocclusion is well-documented. This case report describes the treatment of a 14-year-old male patient with severe Class II Division 1 malocclusion due to retrognathic mandible and mildly prognathic maxilla, convex profile, and lip trap. He had severely(More)
Various anomalies in the size, shape, number, structure and eruption of the teeth are often observed clinical conditions. Supernumerary teeth can be found in almost any region of the dental arch, and most of the times they are asymptomatic, and are routinely found during radiographic evaluation. The most common cause of impacted maxillary incisors is the(More)
  • 1