Manjunath Hegde

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The liver is a heterogeneous organ with many vital functions, including metabolism of pharmaceutical drugs and is highly susceptible to injury from these substances. The etiology of drug-induced liver disease is still debated although generally regarded as a continuum between an activated immune response and hepatocyte metabolic dysfunction, most often(More)
Automatic construction of knowledge graphs (KGs) from unstructured text has received considerable attention in recent research, resulting in the construction of several KGs with millions of entities (nodes) and facts (edges) among them. Unfortunately, such KGs tend to be severely sparse in terms of number of facts known for a given entity, i.e., have low(More)
Although the process of drug development requires efficacy and toxicity testing in animals prior to human testing, animal models have limited ability to accurately predict human responses to xenobiotics and other insults. Societal pressures are also focusing on reduction of and, ultimately, replacement of animal testing. However, a variety of in vitro(More)
The creation of stable flow cultures of hepatocytes is highly desirable for the development of platforms for drug toxicity screening, bio-artificial liver support devices, and models for investigating liver physiology and pathophysiology. Given that hepatocytes cultured using the collagen overlay or in 'sandwich' configuration maintain a wide range of(More)
Hepatocytes and their in vitro models are essential tools for preclinical screening studies for drugs that affect the liver. Most of the current models primarily focus on hepatocytes alone and lack the contribution of non-parenchymal cells (NPCs), which are significant through both molecular and the response of the NPCs themselves. Models that incorporate(More)
The development of long-term human organotypic liver-on-a-chip models for successful prediction of toxic response is one of the most important and urgent goals of the NIH/DARPA's initiative to replicate and replace chronic and acute drug testing in animals. For this purpose, we developed a microfluidic chip that consists of two microfluidic chambers(More)
The creation of stable hepatocyte cultures using cell-matrix interactions has proven difficult in microdevices due to dimensional constraints limiting the utility of classic tissue culture techniques that involve the use of hydrogels such as the collagen "double gel" or "overlay". To translate the collagen overlay technique into microdevices, we modified(More)
In a distributed environment, one of the major concerns is authentication of remote users. In this sector, legitimate users are more powerful attackers. The remote systems working with password and smart card ensures authorised access. Smart card based remote user authentication schemes have been adopted due to their low computation cost and portability. In(More)
Psychosocial neglect during childhood severely impairs both behavioral and physical health. The isolation rearing model in rodents has been employed by our group and others to study this clinical problem at a basic level. We previously showed that immediate early gene (IEG) expression in the hippocampus and medial prefrontal cortex (mPFC) is decreased in(More)
Visualizing 2-D/3-D embeddings of image features can help gain an intuitive understanding of the image category landscape. However, popular visualization methods of visualizing such embeddings (e.g. color-coding by category) are impractical when the number of categories is large. To address this and other shortcomings, we propose novel quantitative measures(More)
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