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Digit regeneration is regulated by Msx1 and BMP4 in fetal mice
The regeneration of digit tips in mammals, including humans and rodents, represents a model for organ regeneration in higher vertebrates. We had previously characterized digit tip regeneration duringExpand
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Limb regeneration in higher vertebrates: developing a roadmap.
We review what is known about amphibian limb regeneration from the prospective of developing strategies for the induction of regeneration in adult mammals. Prominent in urodele amphibian limbExpand
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Development and regeneration of the neonatal digit tip in mice.
The digit tips of children and rodents are known to regenerate following amputation. The skeletal structure that regenerates is the distal region of the terminal phalangeal bone that is associatedExpand
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Wound healing and blastema formation in regenerating digit tips of adult mice.
Amputation of the distal region of the terminal phalanx of mice causes an initial wound healing response followed by blastema formation and the regeneration of the digit tip. Thus far, mostExpand
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BMP signaling induces digit regeneration in neonatal mice
The regenerating digit tip of mice is a novel epimorphic response in mammals that is similar to fingertip regeneration in humans. Both display restricted regenerative capabilities that areExpand
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Mammalian regeneration and regenerative medicine.
Mammals are generally considered to be poor regenerators, yet there are a handful of mammalian models that display a robust ability to regenerate. One such system is the regenerating tips of digitsExpand
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Connective Tissue Fibroblast Properties Are Position-Dependent during Mouse Digit Tip Regeneration
A key factor that contributes to the regenerative ability of regeneration-competent animals such as the salamander is their use of innate positional cues that guide the regeneration process. TheExpand
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BMP2 induces segment-specific skeletal regeneration from digit and limb amputations by establishing a new endochondral ossification center.
Bone morphogenetic proteins (BMPs) are required for bone development, the repair of damage skeletal tissue, and the regeneration of the mouse digit tip. Previously we showed that BMP treatment canExpand
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Regrowing human limbs.
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The mouse digit tip: from wound healing to regeneration.
A challenge to the study of regeneration is determining at what point the processes of wound healing and regeneration diverge. The mouse displays level-specific regeneration responses. An amputationExpand
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