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- Raphaël Itzykson, Olivier Kosmider, +20 authors Éric Solary
- Journal of clinical oncology : official journal…
- 2013
PURPOSE
Several prognostic scoring systems have been proposed for chronic myelomonocytic leukemia (CMML), a disease in which some gene mutations-including ASXL1-have been associated with poor… (More)
- Hideki Makishima, Tetsuichi Yoshizato, +34 authors Jaroslaw Maciejewski
- Nature Genetics
- 2017
To elucidate differential roles of mutations in myelodysplastic syndromes (MDS), we investigated clonal dynamics using whole-exome and/or targeted sequencing of 699 patients, of whom 122 were… (More)
- Manja Meggendorfer, Andreas Roller, +11 authors Susanne Schnittger
- Blood
- 2012
We analyzed the mutational hotspot region of SRSF2 (Pro95) in 275 cases with chronic myelomonocytic leukemia (CMML). In addition, ASXL1, CBL, EZH2, JAK2V617F, KRAS, NRAS, RUNX1, and TET2 mutations… (More)
- Manja Meggendorfer, Ulrike Bacher, +5 authors Susanne Schnittger
- Leukemia
- 2013
Chronic myeloid malignancies are categorized to the three main categories myeloproliferative neoplasms (MPNs), myelodysplastic syndromes (MDSs) and MDS/MPN overlap. So far, no specific genetic… (More)
- Maximilian Mossner, J. Jann, +26 authors Daniel Nowak
- Blood
- 2016
Clonal evolution is believed to be a main driver for progression of various types of cancer and implicated in facilitating resistance to drugs. However, the hierarchical organization of malignant… (More)
- Juliana Schwaab, Susanne Schnittger, +18 authors Andreas Reiter
- Blood
- 2013
To explore mechanisms contributing to the clinical heterogeneity of systemic mastocytosis (SM) and to suboptimal responses to diverse therapies, we analyzed 39 KIT D816V mutated patients with… (More)
- Susanne Weber, Tamara Alpermann, +10 authors Susanne Schnittger
- Blood cancer journal
- 2014
High brain and acute leukemia, cytoplasmic (BAALC) expression defines an important risk factor in cytogenetically normal acute myeloid leukemia (CN-AML). The prognostic value of BAALC expression in… (More)
- Michael Heuser, Manja Meggendorfer, +26 authors Felicitas R Thol
- Leukemia
- 2015
1 O'Hare T, Zabriskie MS, Eiring AM, Deininger MW. Pushing the limits of targeted therapy in chronic myeloid leukaemia. Nat Rev Cancer 2012; 12: 513–526. 2 Gorre ME, Ellwood-Yen K, Chiosis G, Rosen… (More)
- Ulrike Bacher, Torsten Haferlach, +9 authors Claudia Haferlach
- British journal of haematology
- 2014
In patients with myelodysplastic syndromes (MDS), sole 20q deletion [del(20q)] is a recurrent favourable abnormality. We studied additional molecular and cytogenetic lesions and their prognostic… (More)
- Sabit Delic, Dominic Rose, +4 authors Manja Meggendorfer
- British journal of haematology
- 2016
Molecular routine diagnostics for BCR-ABL1-negative myeloproliferative neoplasms (MPN) currently focusses on mutations in JAK2, CALR and MPL. In recent years, recurrent mutations in MPNs have been… (More)