Manisha Pandey

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Vaccination with J8-DT, a leading GAS vaccine candidate, results in protective immunity in mice. Analysis of immunologic correlates of protection indicated a role of J8-specific antibodies that were induced post-immunization. In the present study, several independent experimental approaches were employed to investigate the protective immunological(More)
UNLABELLED Group A Streptococcus (GAS) is an important human pathogen responsible for both superficial infections and invasive diseases. Autoimmune sequelae may occur upon repeated infection. For this reason, development of a vaccine against GAS represents a major challenge, since certain GAS components may trigger autoimmunity. We formulated three(More)
Burn wound management is a complex process because the damage may extend as far as the dermis which has an acknowledged slow rate of regeneration. This study investigates the feasibility of using hydrogel microparticles composed of bacterial cellulose and polyacrylamide as a dressing material for coverage of partial-thickness burn wounds. The(More)
The pursuit of a safe vaccine against Streptococcus pyogenes (group A streptococcus, GAS) that does not induce autoimmune pathology and that affords coverage for most GAS serotypes, has been a major goal for several decades. These infections account for over 500,000 premature deaths every year resulting from deep tissue infections and post-streptococcal(More)
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