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  • Jennifer A A Gubbels, Jennifer A. Belisle, +9 authors Manish S Patankar
  • Biology, Medicine
  • Molecular Cancer
  • 2006 (First Publication: 26 October 2006)
  • BackgroundThe mucin MUC16 and the glycosylphosphatidylinositol anchored glycoprotein mesothelin likely facilitate the peritoneal metastasis of ovarian tumors. The biochemical basis and the kineticsContinue Reading
  • Jennifer A. Belisle, Jennifer A A Gubbels, +4 authors Manish S Patankar
  • Medicine, Biology
  • Immunology
  • 2007 (First Publication: 1 November 2007)
  • The ovarian tumour marker MUC16 (CA125) inhibits the cytotoxic responses of human natural killer (NK) cells and down-regulates CD16. Here we show that approximately 10% of the peripheral blood NKContinue Reading
  • Jennifer A A Gubbels, Brian Gadbaw, +8 authors Joseph F. Connor
  • Biology, Medicine
  • Cancer Immunology, Immunotherapy
  • 2011 (First Publication: 1 December 2011)
  • The huKS-IL2 immunocytokine (IC) consists of IL2 fused to a mAb against EpCAM, while the hu14.18-IL2 IC recognizes the GD2 disialoganglioside. They are under evaluation for treatment of EpCAM+Continue Reading