Manish Kumar Gupta

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A system can be defined as an organized, interconnected structure consisting of interrelated and interdependent elements (e.g., components, factors, members, parts). These parts and processes are connected by structural and/or behavioral relationships and continually influence one another directly or indirectly to maintain a balance essential for the(More)
Malnutrition is well recognized as a potential cause of increased morbidity and mortality in surgical patients. Early postoperative enteral nutrition through a feeding jejunostomy has been shown to improve results in patients undergoing major resections for gastrointestinal malignancies, trauma, and perforation peritonitis. We conducted a prospective study(More)
Alzheimer’s disease (AD) is caused by the accumulation of beta-amyloid (β-A) in the brain that forms amyloid plaque. β-A is an oligo-peptide consisting of 39–42 amino acid residues, produced by proteolytic cleavage of amyloid precursor protein by secretase enzymes. Evolutionary trace and protein family analysis of β-A indicates that C-terminal residues of(More)
The Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase (pfSAHH) enzyme has been considered as a potential chemotherapeutic target against malaria due to the amino acid differences found on binding sites of pfSAHH related to human SAHH. It has been reported that noraristeromycin and some curcumin derivatives have potential binding with the largest(More)
The aim of metabolic modeling was to understand the cause effect interaction and reliance linked with the complex interactions of biological networks and molecular systems. Drugs that therapeutically modulate the biological processes of disease are often developed with limited knowledge of the underlying complexity of their specific targets. The robustness(More)
MicroRNAs (miRNA) are a class of non-coding RNA which inhibits the expression of a particular gene by the process of nucleotide-sequence-specific post-transcriptional gene silencing method. miRNAs are ~21 nt long non-coding RNAs that are derived from larger hairpin RNA precursors. The short length of the miRNA sequences and relatively low conservation of(More)
UNLABELLED A number of plants have been described in Ayurveda and other traditional medicine for the management of diabetes. However, information about them is not easily available. Active constituents of any medicinal plant define the efficacy and safety of treatment to control hyperglycemia. We describe the database to maintain the record of medicinal(More)
The thyroid pathway represents a complex interaction of different glands for thyroid hormone synthesis. Thyrotropin releasing hormone is synthesized in the hypothalamus and regulates thyrotropin stimulating hormone gene expression in the pituitary gland. In order to understand the complexity of the thyroid pathways, and using experimental data retrieved(More)
Fractional Repetition (FR) codes are well known class of Distributed Replication-based Simple Storage (Dress) codes for the Distributed Storage Systems (DSSs). In such systems, the replicas of data packets encoded by Maximum Distance Separable (MDS) code, are stored on distributed nodes. Most of the available constructions for the FR codes are based on(More)
The three-dimensional quantitative structure-activity relationship (3D-QSAR) for inhibitors of thyroid hormone receptors (TR) α and (TR) β was studied. The training set of the TRα model generated a correlation coefficient (R(2)) =  0.9535, with standard deviation (SD) =  0.3016. From the test set of the TRα model, a Q(2) value for the predicted activities(More)