Mangal Singh

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Changes in lipid profile have long been associated with malignancies as lipids play a key role in maintenance of cell integrity. This study evaluated the alterations in extended lipid profile in untreated patients of oral submucous fibrosis (OSMF) and studied the correlation between lipid levels with tobacco consumption. In this hospital-based study, 65(More)
Oral malignancy is a major global health problem. Besides the main risk factors of tobacco, smoking and alcohol, infection by human papillomavirus (HPV) and genetic alterations are likely to play an important role in these lesions. The purpose of this study was to compare the efficacy of HC-II assay and PCR for the detection of specific HPV type (HPV 16 E6)(More)
Matrix metalloproteinases (MMPs) are enzymes that degrade all the components of extra cellular matrix and collagen. Various types of MMPs are known to be expressed and activated in patients with oral submucous fibrosis (OSMF) as well as head and neck squamous cell carcinoma (HNSCC). The purpose of this study was to asses the association of the single(More)
Present prospective study was conducted on 350 patients presenting with chief complaints of impaired hearing and delayed speech from 1996-2006. The aim of the present study was to find out the prevalence of deafmutism in our area, the aetiology of childhood deafness and to ascertain the role of acoustic reflex test (ART) for hearing screening considering(More)
BACKGROUND Cancer of the oral cavity is the sixth most common malignancy reported worldwide and one with the highest mortality rate among all malignancies. There is a paucity of reliable diagnostic methods to detect early malignancies. This study was performed to evaluate the sensitivity and specificity of brush biopsy in identifying oral premalignant and(More)
The aim of this study was to explore the association of MMP-2 (-1306 C/T and -168 G/T) and MMP-9 (-1562 C/T) promoter polymorphisms in oral submucous fibrosis (OSMF) and head and neck squamous cell carcinoma (HNSCC) cases. These SNP were genotyped by PCR-RFLP. Total of 1260 individuals were recruited, of which 412 OSMF, 422 HNSCC and 426 were controls. In(More)
Atrophic rhinitis is a chronic debilitating nasal mucosal disease of unknown etiology. It is characterized by progressive nasal mucosal atrophy, crusting, fetor and enlargement of the nasal space with paradoxical congestion. The disease induces bilateral nasal obstruction and a persistent foul odour of which the patient and by-standers are painfully aware.(More)
Oral submucous fibrosis (OSMF) is a chronic inflammatory condition of oral cavity The common sites of involvement are cheek, tongue and soft palate The pathological changes not only involve the mucosa and submucosa but also extend deeper to involve the underlying muscles Atrophic and degenerative changes in the tubal and paratubal muscles have already been(More)
AIM To determine the effects of high dose irradiation on parotid salivary sodium and pH concentration at subsequent duration of 1.5, 3 and 6 months following radiotherapy. MATERIALS AND METHODS Eighty parotid glands of head and neck cancer patients were irradiated with mean dose of 66 Gy. The stimulated parotid flow (PF) was collected by a cannulation of(More)