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- Michael Froehner, Manfred P Wirth
- The New England journal of medicine
- 2014
Enzalutamide is an oral androgen-receptor inhibitor that prolongs survival in men with metastatic castration-resistant prostate cancer in whom the disease has progressed after chemotherapy. New… (More)
- Monica Cojoc, Claudia Peitzsch, +13 authors Anna Dubrovska
- Cancer research
- 2015
Radiotherapy is a curative treatment option in prostate cancer. Nevertheless, patients with high-risk prostate cancer are prone to relapse. Identification of the predictive biomarkers and molecular… (More)
- David G. Mcleod, Peter Iversen, William A. See, Thomas Morris, Jon Armstrong, Manfred P Wirth
- BJU international
- 2006
OBJECTIVE
To evaluate, in the ongoing Early Prostate Cancer (EPC) trial programme, the efficacy and tolerability of bicalutamide 150 mg once daily in addition to standard care for localized or… (More)
- Thomas Wiegel, Detlef Bartkowiak, +18 authors Kurt Miller
- European urology
- 2014
BACKGROUND
Local failure after radical prostatectomy (RP) is common in patients with cancer extending beyond the capsule. Three prospectively randomized trials demonstrated an advantage for adjuvant… (More)
- Georgios Gakis, Stephen Anthony Boorjian, +8 authors Christian G Stief
- European urology
- 2014
CONTEXT
Because pelvic lymph node (LN)-positive prostate cancer (PCa) is generally considered a regionally metastatic disease, surgery needs to be better defined.
OBJECTIVE
To review the impact of… (More)
Catecholamines relax detrusor through beta 2-adrenoceptors in mouse and beta 3-adrenoceptors in man.
- Melinda Wuest, Birgit Eichhorn, Marc O Grimm, Manfred P Wirth, Ursula Ravens, Alberto Julio Kaumann
- The Journal of pharmacology and experimental…
- 2009
(-)-Isoproterenol [4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]-1,2-benzene diol hydrochloride] relaxes murine detrusor through beta-adrenoceptors (ARs); however, the beta-AR subtypes involved are… (More)
- Melinda Wuest, Nicole Hiller, Manfred Braeter, Oliver Walter Hakenberg, Manfred P Wirth, Ursula Ravens
- European journal of pharmacology
- 2007
Carbachol-induced detrusor contractions are mainly mediated via M3 receptor subtype and depend not only on Ca2+ release from the intracellular calcium stores but also on Ca2+ influx via L-type Ca2+… (More)
- Melinda Wuest, Juliane Hecht, +5 authors Ursula Ravens
- British journal of pharmacology
- 2005
1. Besides its antimuscarinic effects, propiverine may possess an additional mode of action. We compared the effects of propiverine, three of its metabolites (M-5, M-6, M-14) and atropine in human,… (More)
- Oliver Walter Hakenberg, Clemens Linné, Andreas Manseck, Manfred P Wirth
- Neurourology and urodynamics
- 2000
There is evidence that increased bladder wall thickness can be a useful parameter in the evaluation of men with clinical benign prostatic hyperplasia (BPH). However, normal values for bladder wall… (More)
- Daniela Wuttig, Barbara Baier, +8 authors Manfred P Wirth
- International journal of cancer
- 2009
Our understanding of metastatic spread is limited and molecular mechanisms causing particular characteristics of metastasis are largely unknown. Herein, transcriptome-wide expression profiles of a… (More)