Manfred Liebsch

Andrea Seiler2
Christian Riebeling2
Michael Oelgeschläger2
2Andrea Seiler
2Christian Riebeling
2Michael Oelgeschläger
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On the occasion of the 20th anniversary of the Center for Alternative Methods to Animal Experiments (ZEBET), an international symposium was held at the German Federal Institute for Risk Assessment (BfR) in Berlin. At the same time, this symposium was meant to celebrate the 50th anniversary of the publication of the book "The Principles of Humane(More)
The polycyclic aromatic hydrocarbon (PAH) benzo[a]pyrene (BP) is metabolized into a complex pattern of BP derivatives, among which the ultimate carcinogen (+)-anti-BP-7,8-diol-9,10-epoxide (BPDE) is formed to certain extents. Skin is frequently in contact with PAHs and data on the metabolic capacity of skin tissue toward these compounds are inconclusive. We(More)
  • Helena Kandárová, Manfred Liebsch, Elke Genschow, Ingrid Gerner, Dieter Traue, Birgitta Slawik +1 other
  • 2004
An ECVAM-funded prevalidation study (PV) was conducted during 1999 and 2000 to identify in vitro tests capable of reliably distinguishing between skin irritants (I) and non-irritants (NI) according to European Union risk phrases ("R38" or no classification). The tests evaluated were EpiDerm, EPISKIN, PREDISKIN, the non-perfused pig ear method, and the mouse(More)
BACKGROUND In biomedical research, the past two decades have seen the advent of in vitro model systems based on stem cells, humanized cell lines, and engineered organotypic tissues, as well as numerous cellular assays based on primarily established tumor-derived cell lines and their genetically modified derivatives. OBJECTIVE There are high hopes that(More)
Consideration of all relevant scientific information on alternative methods to animal experiments is a statutory part of planning scientific projects in the life sciences. Animals may only be used if the specific scientific goal pursued cannot be achieved by any other means (i.e. non-animal procedures). In order to satisfy this legal requirement the(More)
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