Manfred Lacher

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The combination of an integrated Mach-Zehnder-interferometer (iMZI) at the bottom of a fluidic microchannel system with supramolecular interfacial binding layers optimized for biosensing purposes is described. The model system used is based on the highly specific interaction of streptavidin to its 'ligand' biotin: a single monolayer of a correspondingly(More)
We report the implementation of an electrostatic Einzel lens (Boersch) phase plate in a prototype transmission electron microscope dedicated to aberration-corrected cryo-EM. The combination of phase plate, C(s) corrector and Diffraction Magnification Unit (DMU) as a new electron-optical element ensures minimal information loss due to obstruction by the(More)
Implementation of physical phase plates into transmission electron microscopes to achieve in-focus contrast for ice-embedded biological specimens poses several technological challenges. During the last decade several phase plates designs have been introduced and tested for electron cryo-microscopy (cryoEM), including thin film (Zernike) phase plates and(More)
In the area of biomimetics, engineers use inspiration from natural systems to develop technical devices, such as sensors. One example is the lateral line system of fish. It is a mechanoreceptive system consisting of up to several thousand individual sensors called neuromasts, which enable fish to sense prey, predators, or conspecifics. So far, the small(More)
Beetles of the genus Melanophila acuminata detect forest fires from distances as far as 130 km with infrared-sensing organs. Inspired by this extremely sensitive biological device, we are developing an IR sensor that operates at ambient temperature using MEMS technology. The sensor consists of two liquid-filled chambers that are connected by a micro-fluidic(More)
The most common resist used for LIGA applications with deep X-ray lithography is PMMA. It achieves very good resolution of the mask structures with a typical resist thickness from 200 μm to 2 mm. The resist system employed here is crosslinked on the substrate after preparation, and this can lead to problems with internal stresses and resist cracking. To(More)
STUDY OBJECTIVE To evaluate the appropriateness of lights and siren (L&S) in the transport of pediatric patients by ambulance/emergency medical vehicle in a region with no specific guidelines regarding L&S use. METHODS We reviewed audiotapes of eligible calls made during a 7-month period to a pediatric medical control center (PMCC) at a children's(More)
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