Manfred L. Ristig

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Voltage-activated ion channels vary randomly between open and closed states, influenced by the membrane potential and other factors. Signal transduction is enhanced by noise in a simple ion channel model. The enhancement occurs in a finite range of signals; the range can be extended using populations of channels. The range increases more rapidly in(More)
Active Ca2+ transport in living cells necessitates controlled supply of metabolic energy. Direct coupling between sarco/endoplasmic reticulum (ER) Ca2+ ATPases (SERCA) and intracellular energy-generation sites has been well established experimentally. On the basis of these experimental findings we propose a pump-driven model to investigate complex dynamic(More)
J. Dawidowski,1,* F. J. Bermejo,2,† M. L. Ristig,3 C. Cabrillo,4 and S. M. Bennington5 1Consejo Nacional de Investigaciones Científicas y Técnicas, Centro Atómico Bariloche and Instituto Balseiro, Comisión Nacional de Energía Atómica, Universidad Nacional de Cuyo, (8400) Bariloche, Argentina 2C.S.I.C., Department of Electricity and Electronics, University(More)
Thomas Lindenau, Manfred L. Ristig, Klaus A. Gernoth, Javier Dawidowski, and Francisco J. Bermejo Institut für Theoretische Physik, Universität zu Köln D–50937 Köln, Germany ristig@thp.uni-koeln.de School of Physics and Astronomy, The University of Manchester Manchester, United Kingdom k.a.gernoth@man.ac.uk Consejo Nacional de Investigationes Cientificas y(More)
We consider signal transaction in a simple neuronal model featuring intrinsic noise. The presence of noise limits the precision of neural responses and impacts the quality of neural signal transduction. We assess the signal transduction quality in relation to the level of noise, and show it to be maximized by a non-zero level of noise, analogous to the(More)
J. Dawidowski,* F. J. Bermejo, M. L. Ristig, B. Fåk, C. Cabrillo, R. Fernández-Perea, K. Kinugawa, and J. Campo Consejo Nacional de Investigaciones Cientı́ficas y Técnicas, Centro Atómico Bariloche and Instituto Balseiro, Comisión Nacional de Energı́a Atómica, Universidad Nacional de Cuyo, (8400) Bariloche, Argentina Department of Electricity and(More)
An explicit structural connection is established between the Bayes optimal classifier operating on K binary input variables and a corresponding two-layer perceptron having normalized output activities and couplings from input to output units of all orders up to K. With suitable modification of connection weights and biases, such a higher-order probabilistic(More)
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