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BACKGROUND The use of warfarin reduces the rate of ischemic stroke in patients with atrial fibrillation but requires frequent monitoring and dose adjustment. Rivaroxaban, an oral factor Xa inhibitor, may provide more consistent and predictable anticoagulation than warfarin. METHODS In a double-blind trial, we randomly assigned 14,264 patients with(More)
BACKGROUND Vitamin K antagonist (VKA) therapy remains the most common method of stroke prevention in patients with atrial fibrillation. Time in therapeutic range (TTR) is a widely cited measure of the quality of VKA therapy. We sought to identify factors associated with TTR in a large, international clinical trial. METHODS AND RESULTS TTR (international(More)
by the American College of Cardiology Foundation American Heart Association Science Advisory and uly 2011, by the Society of Cardiovascular Anesthesioracic Surgeons in August 2011, and by the American ery in September 2011. Cardiology Foundation requests that this document D, Smith PK, Anderson JL, Bittl JA, Bridges CR, esa VJ, Hiratzka LF, Hutter AM Jr,(More)
CONTEXT Acute ST-segment elevation myocardial infarction (STEMI) is a leading cause of morbidity and mortality. In experimental models of MI, erythropoietin reduces infarct size and improves left ventricular (LV) function. OBJECTIVE To evaluate the safety and efficacy of a single intravenous bolus of epoetin alfa in patients with STEMI. DESIGN, SETTING,(More)
We investigated whether: (1) EEG recordings could be successfully performed in an MRI imager, (2) subclinical epileptic discharges could be used to trigger ultrafast functional MRI images, (3) artifact-free functional MRI images could be obtained while the patient was having the EEG monitored, and (4) the functional MRI images so obtained would show focal(More)
Manesh R. Patel, MD, Chair; Hani Jneid, MD; Colin P. Derdeyn, MD, FAHA; Lloyd W. Klein, MD, FAHA; Glenn N. Levine, MD, FAHA; Robert A. Lookstein, MD, FAHA; Christopher J. White, MD, FAHA; Yerem Yeghiazarians, MD, FAHA; Kenneth Rosenfield, MD; on behalf of the American Heart Association Diagnostic and Interventional Cardiac Catheterization Committee of the(More)
IMPORTANCE Studies in experimental and human heart failure suggest that phosphodiesterase-5 inhibitors may enhance cardiovascular function and thus exercise capacity in heart failure with preserved ejection fraction (HFPEF). OBJECTIVE To determine the effect of the phosphodiesterase-5 inhibitor sildenafil compared with placebo on exercise capacity and(More)
OBJECTIVE We assessed CT-guided percutaneous injection of fibrin glue to manage meningeal cysts of the sacral spine in patients with back pain. CONCLUSION All patients experienced resolution or marked improvement of symptoms for as long as 23 months after fibrin glue therapy. No patients experienced recurrence of symptoms during the follow-up interval.(More)
AIMS Patients with non-valvular atrial fibrillation (AF) and renal insufficiency are at increased risk for ischaemic stroke and bleeding during anticoagulation. Rivaroxaban, an oral, direct factor Xa inhibitor metabolized predominantly by the liver, preserves the benefit of warfarin for stroke prevention while causing fewer intracranial and fatal(More)