Mandy K. Mason

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Sonic hedgehog (Shh) plays an integral role in both the anterior-posterior (A-P) patterning and expansion of developing vertebrate limbs through a feedback loop involving Fgfs, Bmps, and Gremlin. In bat limbs A-P patterning and the size of the digital field are unique. The posterior digits of the forelimb are elongated and joined by tissue, whereas the(More)
Comparative embryology expands our understanding of unique limb structures, such as that found in bats. Bat forelimb digits 2 to 5 are differentially elongated and joined by webbing, while the hindlimb digits are of similar length in many species. We compare limb development between the mouse and the Natal long-fingered bat, Miniopterus natalensis, to(More)
Bats are the only mammals capable of powered flight, but little is known about the genetic determinants that shape their wings. Here we generated a genome for Miniopterus natalensis and performed RNA-seq and ChIP-seq (H3K27ac and H3K27me3) analyses on its developing forelimb and hindlimb autopods at sequential embryonic stages to decipher the molecular(More)
The molecular events leading to the development of the bat wing remain largely unknown, and are thought to be caused, in part, by changes in gene expression during limb development. These expression changes could be instigated by variations in gene regulatory enhancers. Here, we used a comparative genomics approach to identify regions that evolved rapidly(More)
Did segmented body plans evolve just once, or repeatedly among the animals? This question has become all the more controversial, now that molecular phylogenetic trees make it clear that the three major clades of segmented animals, vertebrates, annelids and the pan-arthropoda, each lies within a different major clade of the animals. If we are to have any(More)
The bat has strikingly divergent forelimbs (long digits supporting wing membranes) and hindlimbs (short, typically free digits) due to the distinct requirements of both aerial and terrestrial locomotion. During embryonic development, the morphology of the bat forelimb deviates dramatically from the mouse and chick, offering an alternative paradigm for(More)
The first lineage allocation during mouse development results in the trophectoderm and inner cell mass at the blastocyst stage. The caudal-related transcription factor, CDX2, is upregulated and required for the repression of inner cell mass genes Oct 4 and Nanog in the trophectoderm to specify the two lineages. Mouse embryos are precocious implanters(More)
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