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Actin is one of the most conserved proteins in nature. Its assembly and disassembly are regulated by many proteins, including the family of actin-depolymerizing factor homology (ADF-H) domains. ADF-H domains can be divided into five classes: ADF/cofilin, glia maturation factor (GMF), coactosin, twinfilin, and Abp1/drebrin. The best-characterized class is(More)
  • William O’Grady, Amy Schafer, +13 authors Zhijun Wen
  • 2009
A major obstacle to the early diagnosis of language loss and to the assessment of language maintenance efforts is the absence of an easy-to-use psycholinguistic measure of language strength. In this paper, we describe and discuss a body-part naming task being developed as part of the Hawai‘i Assessment of Language Access (HALA) project. This task, like the(More)
Language comprehenders can mentally simulate perceptual and motor features of scenes they hear or read about (Barsalou, 1999; Glenberg & Kaschak, 2002; Zwaan, Stanfield, & Yaxley, 2002). Recent research shows that these simulations adopt a particular perspective (Borghi, Glenberg, & Kaschak, 2004; Brunyé, Ditman, Mahoney, Augustyn, & Taylor, 2009).(More)
The WW domain is known as one of the smallest protein modules with a triple-stranded beta-sheet fold. Here, we present the solution structure of the second WW domain from the mouse salvador homolog 1 protein. This WW domain forms a homodimer with a beta-clam-like motif, as evidenced by size exclusion chromatography, analytical ultracentrifugation and NMR(More)
The acid-treated single-walled carbon nanotubes (SWCNTs) dispersed in water are only kinetically stable with electrostatic double layer repulsions just balancing against van der Waals (VDW) attractions. Introducing any external factor to disturb this balance causes immediate coagulation of SWCNTs. Here, an amine-covered flat substrate was immersed in the(More)
Human RNA helicase II/Gu alpha (RH-II/Gu alpha) and RNA helicase II/Gu beta (RH-II/Gu beta) are paralogues that share the same domain structure, consisting of the DEAD box helicase domain (DEAD), the helicase conserved C-terminal domain (helicase_C), and the GUCT domain. The N-terminal regions of the RH-II/Gu proteins, including the DEAD domain and the(More)
Dept. of Bioengineering and Robotics, Graduate School of Eng., Tohoku University. 6-6-01 Aza Aoba, Aramaki, Aoba-ku, Sendai 980-8579, Japan Phone: +81-22-795-6906 E-mail: sdlab@sd.mech.tohoku.ac.jp Biofunctional Science, Tohoku University Biomedical Engineering Research Organization 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan Ophthtalmology, Tohoku(More)
We report on two experiments that ask when and under what linguistic conditions comprehenders construct detailed shape representations of mentioned objects, and whether these can change over the course of a sentence when new information contradicts earlier expectations. We used Japanese because the verb-final word order of Japanese presented a revealing(More)
We have recently identified from the avian hypothalamus a complementary DNA encoding a small secretory protein termed neurosecretory protein GL (NPGL). In chicks, NPGL increases body weight gain without affecting food intake. A database search reveals that NPGL is conserved throughout vertebrates. However, the central distribution and functional role of(More)