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  • Wen-Quan Zou, S Capellari, Piero Parchi, Man-Sun Sy, Pierluigi Gambetti, Shu Guang Chen
  • Biology, Medicine
  • The Journal of biological chemistry
  • 2003 (First Published: 17 October 2003)
  • The central event in the pathogenesis of prion diseases, a group of fatal, transmissible neurodegenerative disorders including Creutzfeldt-Jakob disease (CJD) in humans, is the conversion of theContinue Reading
  • Shaoman Yin, Nancy Pham, +8 authors Man-Sun Sy
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2007 (First Published: 1 May 2007)
  • Mutation in the prion gene PRNP accounts for 10-15% of human prion diseases. However, little is known about the mechanisms by which mutant prion proteins (PrPs) cause disease. Here we investigatedContinue Reading
  • Alessio Cardinale, Ilaria Filesi, Vito Vetrugno, Maurizio Pocchiari, Man-Sun Sy, Silvia Biocca
  • Biology, Medicine
  • The Journal of biological chemistry
  • 2005 (First Published: 7 January 2005)
  • The conversion of the normal cellular prion protein (PrP(C)) into the abnormal scrapie isoform (PrP(Sc)) is a key feature of prion diseases. The pathogenic mechanisms and the subcellular sites of theContinue Reading