• Publications
  • Influence
Effects of all-trans-retinoic acid on human SH-SY5Y neuroblastoma as in vitro model in neurotoxicity research.
TLDR
It is hypothesized that modulation of signaling pathways and neuronal properties during RA-mediated differentiation in SH-SY5Y cells can affect their susceptibility to neurotoxins, and undifferentiated SH- SY5Y is more appropriate for studying neurotoxicity or neuroprotection in experimental Parkinson's disease research. Expand
Neuroprotective effects of anti-aging oriental medicine Lycium barbarum against β-amyloid peptide neurotoxicity
TLDR
Investigation of natural plant extracts of Lycium barbarum aimed to investigate whether extracts from L. barbarum have neuroprotective effects against toxicity of fibrillar Abeta(1-42) and Abeta (25-35) fragments proved the hypothesis by showing neuroprot protective effects of the extract. Expand
Dietary oxyresveratrol prevents parkinsonian mimetic 6-hydroxydopamine neurotoxicity.
TLDR
OXY, a dietary phenolic compound, is suggested as a potential nutritional candidate for protection against neurodegeneration in PD by suggesting that OXY may act as an intracellular antioxidant to reduce oxidative stress induced by 6-OHDA. Expand
Protective effects of pinostilbene, a resveratrol methylated derivative, against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells.
TLDR
The potential of methylated stilbenes in neuroprotection is demonstrated and mammalian target of rapamycin kinase may be an intracellular target accounting for the neuroprotective effects of pinostilbene. Expand
Huntingtin mediates dendritic transport of β-actin mRNA in rat neurons
TLDR
It is reported that Htt and the huntingtin-associated protein 1 (HAP1) are co-localized with the microtubule motor proteins, the KIF5A kinesin and dynein, during dendritic transport of β-actin mRNA. Expand
Neuroprotective effects of polysaccharides from wolfberry, the fruits of Lycium barbarum, against homocysteine-induced toxicity in rat cortical neurons.
TLDR
The data demonstrated that LBA exerted neuroprotective effects on cortical neurons exposed to Hcy, which has the potential to be a diseasemodifying agent for the prevention of AD. Expand
Upstream Signaling Pathways Leading to the Activation of Double-stranded RNA-dependent Serine/Threonine Protein Kinase in β-Amyloid Peptide Neurotoxicity*
TLDR
It is reported here that inhibition of caspase-3 activity reduces phosphorylation of PKR and to a certain extent, cleavage ofPKR and eIF2α in neurons exposed to Aβ peptide. Expand
Polysaccharides from Wolfberry Antagonizes Glutamate Excitotoxicity in Rat Cortical Neurons
TLDR
LBA exerted significant neuroprotective effects on cultured cortical neurons exposed to glutamate and attenuated N-methyl-d-aspartate (NMDA)-induced neuronal damage. Expand
Cytoprotective effects of Lycium barbarum against reducing stress on endoplasmic reticulum.
TLDR
Using a reducing agent, dithiothreitol (DTT), LBG exhibits cytoprotective effects against reducing stress by lowering the DTT-induced LDH release and caspase-3 activity, and it is found that LBG attenuates D TT-induced PERK phosphorylation. Expand
New polysaccharide from Nerium indicum protects neurons via stress kinase signaling pathway
TLDR
Taken together, the polysaccharide J6 isolated from the flowers of N. indicum can serve as potential neuroprotective agent against neuronal death in Alzheimer's disease and the neuroProtective mechanism may primarily rely on inactivation of JNK signaling pathway. Expand
...
1
2
3
...