Man Sang Chau

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DNA damage inactivates cyclin-dependent kinases (CDKs) and arrests the cell cycle. Following DNA damage, the G1-S CDKs are inhibited by a mechanism involving p53-dependent induction of p21Cip1/Waf1; but how the Cdc2 is inhibited is less apparent. We found that the signal generated by the DNA damage checkpoint in G2 was dominant over that from the spindle(More)
degraded or dissociates (5). The activity of CDKs is negatively regulated by phosphorylation of Thr14 and Tyr'5, and by binding to CDK inhibitors, which include the p21 family (p21@h/@@5f1, p27†• @†• , and p57IUP2) and the p16INK4A family (p16INK4A, p155NK4B pl8IN@, p19INK4D; Ref. 6). Thr@ and Tyr'5 of Cdc2 are phospho rylated by Wed and Myti and(More)
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