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Dysregulation of p53-RBM25-mediated circAMOTL1L biogenesis contributes to prostate cancer progression through the circAMOTL1L-miR-193a-5p-Pcdha pathway
These findings have linked p53/RBM25-mediated circAMOTL1L-miR-193a-5p-Pcdha8 regulatory axis to EMT in metastatic progression of PCa, and Targeting this newly identified regulatory axis provides a potential therapeutic strategy for aggressive PCa. Expand
A Novel Regulatory Mechanism of Smooth Muscle &agr;-Actin Expression by NRG-1/circACTA2/miR-548f-5p Axis
In vivo studies demonstrated that the localization of the interaction of circACTA2 with miR-548f-5p is significantly decreased in human intimal hyperplastic arteries compared with normal arteries, implicating that dysregulation of circ ACTA2 and miR/miR/548f/5p expression is involved in intimalhyperplasia. Expand
iNOS-derived peroxynitrite mediates high glucose-induced inflammatory gene expression in vascular smooth muscle cells through promoting KLF5 expression and nitration.
The present findings were the first to show that KLF5 expression and nitration by iNOS-mediated peroxynitrite are necessary for the induction of TNF-α and IL-1β expression in VSMCs of diabetic vascular tissues. Expand
Silencing of miR-193a-5p increases the chemosensitivity of prostate cancer cells to docetaxel
  • Zhan Yang, Jin-Suo Chen, +11 authors Yong Zhang
  • Chemistry, Medicine
  • Journal of experimental & clinical cancer…
  • 8 December 2017
Limiting the expression of Bach2, a repressor of the HO-1 gene, by directly targeting the Bach2 mRNA 3′-UTR may be a novel therapeutic approach for castration-resistant PC through silencing or blockade of the miR-193a-5p-Bach2-HO-1 pathway. Expand
Loss of fragile histidine triad and amplification of 1p36.22 and 11p15.5 in primary gastric adenocarcinomas.
These regions, especially the focal amplicons, may harbor key driver genes that will serve as biomarkers for either the diagnosis or the prognosis of gastric cancer, and therefore, a large-scale investigation is recommended. Expand
Oncogenic functions of the EMT-related transcription factor ZEB1 in breast cancer
Current evidence suggests that ZEB1 stimulates tumor cells with mesenchymal traits and promotes multidrug resistance, proliferation, and metastasis, indicating the importance of Z EB1-induced EMT in cancer development. Expand
Clinical significance of connective tissue growth factor in hepatitis B virus-induced hepatic fibrosis.
AIM To determine the utility of connective tissue growth factor (CCN2/CTGF) for assessing hepatic fibrosis in hepatitis B virus (HBV)-induced chronic liver diseases (CLD-B). METHODS Enzyme-linkedExpand
SHP-1 Phosphatase Is a Critical Regulator in Preventing Natural Killer Cell Self-Killing
Gene silencing of the SHP-1 in primary NK cells abrogated the ability of ITIM-containing NK inhibitory receptors to suppress the activation signals induced by NK1.1 activating receptors and “de-regulated” these SHp-1 knockdown NK cells mediated specific self-killing in a real-time live cell microscopic imaging system developed to study NK cell cytotoxicity in vitro. Expand
Analysis of the Differentially Expressed Genes Induced by Cisplatin Resistance in Oral Squamous Cell Carcinomas and Their Interaction
The molecular mechanisms underlying cisplatin resistance in OSCC are investigated, analyzing the differentially expressed genes (DEGs) and their regulatory relationship, to clarify the molecular basis of OSCC chemotherapy resistance and provide a theoretical foundation for the treatment of patients with OSCC and individualized therapeutic targets accurately. Expand
Fanconi Anemia Pathway: Mechanisms of Breast Cancer Predisposition Development and Potential Therapeutic Targets
The clinical and mechanistic implications of the predisposition of individuals with abnormalities in the FA pathway to cancer, especially breast cancer, are reviewed. Expand