Mamunur Rashid

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Rho-kinase (ROCK) is one of the downstream effectors of the small G-protein Rho. The Rho-ROCK pathway has an important role in mediating various cellular functions, including contraction, actin cytoskeleton organization, cell adhesion and motility, proliferation, cytokinesis and gene expression, all of which are involved in the pathogenesis of(More)
BACKGROUND In developing countries, immunisation programmes must compete with other strategies to improve public health and quality of life. Studies of long-term effects of immunisation programmes are rare. We assessed associations between vaccinations and mortality over 15 years after the introduction of routine infant immunisation programmes in Matlab,(More)
We performed an open, randomized chemotherapy trial comparing the recommended first-, second- and third-line drug regimens, as well as mefloquine, for uncomplicated falciparum malaria in Bangladesh in 1996-97. The regimens were chloroquine for 3 days (CQ, Group I), quinine sulphate for 3 days followed by single-dose sulfadoxine-pyrimethamine (Q3 + SP, Group(More)
Effects of Ramadan fasting on serum lipids of 20 healthy males in Bangladesh were assessed. Anthropometric parameters and blood lipids were measured 1 day before Ramadan, day 26 of Ramadan and 1 month after Ramadan. Body weight and body mass index decreased significantly during Ramadan compared with before and after Ramadan. Fat intake was significantly(More)
BACKGROUND Alzheimer's disease (AD) is a progressive neurodegenerative disorder clinically characterized by loss of memory and cognition. The effective therapeutic options for AD are limited and thus there is a demand for new drugs. Aegle marmelos (Linn.) (A. marmelos) leaves have been used in traditional medicine to promote intellect and enhance memory. In(More)
BACKGROUND The use of plants and their derived substances increases day by day for the discovery of therapeutic agents owing to their versatile applications. Current research is directed towards finding naturally-occurring antioxidants having anticancer properties from plant origin since oxidants play a crucial role in developing various human diseases. The(More)
OBJECTIVE To describe proportionate mortality and causes of death unrelated to pregnancy. DESIGN Prospective cohort study. SETTING Rural northwest Bangladesh. POPULATION A cohort of 133,617 married women of reproductive age. METHODS Verbal autopsies were conducted for women who died whilst under surveillance in the cohort trial. Physician-assigned(More)
OBJECTIVE Oral vaccine efficacy is low in less-developed countries, perhaps due to intestinal dysbiosis. This study determined if stool microbiota composition predicted infant oral and parenteral vaccine responses. METHODS The stool microbiota of 48 Bangladeshi infants was characterized at 6, 11, and 15 weeks of age by amplification and sequencing of the(More)
BACKGROUND The pleiotropic effects of HMG-CoA reductase inhibitors (statins) are thought to be mediated through inhibition of small GTP-binding proteins; however, it remains to be examined whether clinical concentrations/doses of statins actually exert them. METHODS AND RESULTS In vitro studies with cultured human umbilical venous endothelial cells found(More)