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NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells.
It is suggested that multiple immunological dysfunctions, including cytokine production capability, in addition to functional incompetence of T, B, and NK cells, may lead to the high engraftment levels of xenograft in NOD/SCID/gamma(c)(null) mice. Expand
A selective Sema3A inhibitor enhances regenerative responses and functional recovery of the injured spinal cord
Rats treated with Sema3A showed substantially enhanced regeneration and/or preservation of injured axons, robust Schwann cell–mediated myelination and axonal regeneration in the lesion site, appreciable decreases in apoptotic cell number and marked enhancement of angiogenesis, resulting in considerably better functional recovery. Expand
The analysis of the functions of human B and T cells in humanized NOD/shi-scid/gammac(null) (NOG) mice (hu-HSC NOG mice).
The results demonstrate that further improvements are necessary before humanized mice with a functional human immune system are achieved, and it is found that multiple mechanisms were involved in the T-cell abnormalities. Expand
Generation of transgenic non-human primates with germline transmission
It is shown that the injection of a self-inactivating lentiviral vector in sucrose solution into marmoset embryos results in transgenic common marmosets that expressed the transgene in several organs. Expand
Stem Cell-Like Properties of the Endometrial Side Population: Implication in Endometrial Regeneration
Results indicate that putative endometrial stem cells are highly enriched in the ESP cells, which suggest that ESP cells might drive physiological endometrium regeneration and be involved in the pathogenesis of endometriosis. Expand
Accumulation of oxidative DNA damage restricts the self-renewal capacity of human hematopoietic stem cells.
It is demonstrated that serial transplantation of human HSCs into immunodeficient mice triggers replication stress that induces incremental elevation of intracellular reactive oxygen species (ROS) levels and the accumulation of persistent DNA damage within the human H SCs. Expand
Aromatase (Cyp19) expression is up-regulated by targeted disruption of Dax1.
DAX-1 [dosage-sensitive sex reversal, adrenal hypoplasia congenita (AHC) critical region on the X chromosome, gene 1] is an orphan nuclear receptor that represses transcription by steroidogenicExpand
The reconstituted 'humanized liver' in TK-NOG mice is mature and functional.
A novel experimental in vivo platform for replacing mouse liver with functioning human liver tissue that had zonal position-specific enzyme expression and a global gene expression pattern representative of mature human liver and could generate a human-specific profile of drug metabolism is developed. Expand
Interleukin 12–dependent Interferon γ Production by CD8α+Lymphoid Dendritic Cells
The data indicated that dendritic cells are potent in producing IFN-γ in response to IL-12 produced by bacterial infection and play an important role in innate immunity and subsequent T helper cell type 1 development in vivo. Expand
Reconstitution of the functional human hematopoietic microenvironment derived from human mesenchymal stem cells in the murine bone marrow compartment.
Human MSC-derived cells that reconstituted the HME appeared to contribute to the maintenance of human hematopoiesis by actively interacting with primitive human heMatopoietic cells. Expand