Mami Hiraoka

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In order to prevent Alzheimer disease (AD), relationship between single nucleotide polymorphisms (SNPs) of methylene tetrahydrofolate reductase (MTHFR) and folate-homocysteine metabolism was studied. Subjects were 10 males and 42 females (87.9 +/- 7.7 years old) in the special nursing homes for the elderly. Their average care level was 4.2 +/- 0.9, and(More)
Elevated serum total homocysteine (tHcy) levels are associated with increased risk for cardiovascular disease and dementia. The prevalence rates of homozygous mutants among Japanese women (n = 300) were 17.3%, 1.3%, 18.6%, and 5.3% for methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, reduced folate carrier (RFC-1) A80G, and methionine synthase(More)
4. Lenz T, Thiede HM, Nussberger J, Atlas SA, Distler A, Schulte KL (1992) Hyperreninemia and secondary hyperaldostronism in a patient with pheochromocytoma and von Hippel-Lindau disease. Nephron 62 : 345-350 5. Vetter H, Vetter W, Warnholz C, Bayer JM, K/iser H, Vielhaber K, Krtick F (1976) Renin and aldosterone secretion in pheochromocytoma. Am J Med 60 :(More)
Dual-energy X-ray absorptiometry was used to measure bone mineral density (BMD) in the lumbar spine, proximal femur and distal radius in 48 Japanese children aged 3–18 years. In the normal children (n=32), BMD increased with age in all locations, with a nearly twofold increase from preschool age to adolescence. Most of the children with chronic diseases(More)
  • Mami Hiraoka
  • Journal of nutritional science and vitaminology
  • 2004
Various factors influence folate status and requirements. To investigate the folate status in young Japanese women (n=340, 20-22 y), I determined the serum folate and total homocysteine (tHcy), and examined the influence of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism on folate status in a subgroup of 252 of the women. I calculated folate(More)
The introduction of mandatory fortification of grains with folate in 1998 in the United States resulted in 767 fewer spina bifida cases annually and a cost saving of $603 million per year. However, far more significant medical cost savings result from preventing common diseases, including myocardial infarction, stroke, dementia and osteoporosis. A(More)
A low-cost and simple on-site technique for genotyping single nucleotide polymorphisms (SNPs) was developed. The technique is based on allele-specific primer PCR and the recently developed bead arrays in a single tip technique. The performance of the method was verified by genotyping four SNPs that correlate with cardiovascular diseases.
  • M Hiraoka
  • Journal of nutritional science and vitaminology
  • 2001
To investigate the vitamin status of young Japanese women, dietary intakes of vitamin A, E, C, B1, B2, B6, B12, niacin, folate, and beta-carotene were assessed by a 3-d weighed food record in 150 female students aged 21-22. Whole blood levels of vitamin B1, B2, and nicotinic acid, and serum levels of retinol, alpha-tocopherol, vitamin B6, and beta-carotene(More)
Although several studies have reported associations of depressive state with specific nutrients and foods, few have examined the associations with dietary patterns in adults. We investigated the association between major dietary patterns and depressive symptoms in Japanese patients with depression. Subjects were 166 Japanese patients (104 men and 62 women),(More)