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Normothermic ex vivo liver perfusion using steen solution as perfusate for human liver transplantation: First North American results
TLDR
Liver preservation with normothermic ex vivo perfusion with the Metra device using Steen solution is safe and results in comparable outcomes to CS after LT, and using US Food and Drug Administration–approved Steen Solution will avoid a potential regulatory barrier in North America.
Predictors of De Novo Nonalcoholic Fatty Liver Disease After Liver Transplantation and Associated Fibrosis
TLDR
Diabetes, BMI, weight gain after LT, and sirolimus‐based immunosuppression, in keeping with insulin resistance, were the only modifiable factors associated with development of de novo NAFLD.
Systematic integrative analysis of gene expression identifies HNF4A as the central gene in pathogenesis of non-alcoholic steatohepatitis
TLDR
It is discovered that HNF4A is the central gene in the network of NASH connected to metabolic diseases and that it regulates HNF1A, an additional transcription regulator also involved in lipid metabolism.
Liver Transplantation for Acute Liver Failure Due to Dengue Fever
TLDR
It is reported, for the first time to the authors' knowledge, a patient with DF-induced ALF who underwent liver transplantation who underwent Liver transplantation is reported to have suffered from acute liver failure.
Implication of the intestinal microbiome in complications of cirrhosis
TLDR
The PubMed database was searched from January 2000 to May 2015 for studies and review articles on the composition, pathophysiologic effects and therapeutic modulation of the IM in cirrhosis, and the results were evaluated for pertinence to the subject of IM and Cirrhosis.
The impact of preexisting and posttransplant diabetes mellitus on outcomes following liver transplantation.
TLDR
Pre-DM increases the risk of ESRD and mCVE; however, patient survival was comparable to those with PTDM and without diabetes, and understanding the impact of PTDM would need prolonged follow-up.
The hippo pathway: A master regulator of liver metabolism, regeneration, and disease
The liver is the only visceral organ in the body with a tremendous capacity to regenerate in response to insults that induce inflammation, cell death, and injury. Liver regeneration is a complicated
What Is Hot and New in Basic and Translational Science in Liver Transplantation in 2019? Report of the Basic and Translational Research Committee of the International Liver Transplantation Society
TLDR
5 main themes: liver immunobiology and tolerance, ischemia/reperfusion injury and organ preservation, bioengineering and liver regeneration, hepatic primary tumor biology, and pathophysiology of liver failure are summarized.
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