In stable schizophrenic outpatients with predominantly "defect state" symptomatology amphetamine caused a reduction in negative symptoms that was statistically significant but not complete (i.e. these symptoms remained clinically discernible). The possibility that dopaminergic hypofunction contributes some elements to the schizophrenic defect state is… (More)
Twenty-five schizophrenic outpatient subjects in a depot neuroleptic discontinuation study received an amphetamine challenge approximately 6 weeks after their last dose. Only five of these showed greater than three-point increases in positive symptoms on the BPRS, and all five relapsed within 30 days of the challenge. The 20 with less than three-point… (More)
OBJECTIVE The purpose of this study was to investigate the adult outcome of a group of male juveniles who committed sexual assault. METHOD Nineteen sexually assaultive male juveniles and a comparison group of 58 violent juveniles were studied over an 8-year period through use of criminal records and clinical interviews. RESULTS Although in adolescence… (More)
Preclinical and clinical observations suggest that enhancement of prostaglandin activity inhibits catecholamine release and may have antidyskinetic effects. A double-blind therapeutic trial with prostaglandin precursor essential fatty acids was conducted in 16 patients with tardive dyskinesia. No beneficial effects were seen.
OBJECTIVE To evaluate the safety, tolerability, and benefit of fluvoxamine for the treatment of major depressive disorder or anxiety disorders in children and adolescents with cancer. METHOD The study was conducted from 2001 to 2004 at a pediatric hematology-oncology center. Fifteen children and adolescents with cancer were treated with fluvoxamine 100… (More)
A total of 2250 subjects from psychiatric and geriatric settings was examined for abnormal involuntary movements by the same team of trained raters employing a standard examination technique and rating scale. "Spontaneous" dyskinesia rates were 1.3% among 400 healthy elderly people surveyed at senior citizens centers, 4.8% among medical geriatric inpatients… (More)
The age of onset of affective illness as measured by the initial psychiatric consultation for four affective subtypes was evaluated. Bipolar I (mean age = 28.00) and cyclothymics (mean age = 27.58) sought psychiatric consultation for their affective symptoms significantly earlier than unipolar patients (mean age = 34.69). Bipolar II patients (mean age =… (More)
49 patients with primary affective disorders maintained on lithium were evaluated over a 6-month course and the pattern of 10 well-known innocuous side effects of lithium therapy was closely evaluated. The patients had significantly more side effects in the 1st month as opposed to the 4th through 6th months. The difference was statistically significant… (More)