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Cooperation of the ErbB2 receptor and transforming growth factor beta in induction of migration and invasion in mammary epithelial cells.
MCF10A mammary epithelial cells form growth-arrested structures when cultured in three-dimensional basement membrane gels. Activation of the receptor tyrosine kinase ErbB2 induces formation ofExpand
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Proteome-scale purification of human proteins from bacteria
The completion of the human genome project and the development of high-throughput approaches herald a dramatic acceleration in the pace of biological research. One of the most compelling next stepsExpand
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High-throughput generation of P. falciparum functional molecules by recombinational cloning.
Large-scale functional genomics studies for malaria vaccine and drug development will depend on the generation of molecular tools to study protein expression. We examined the feasibility of aExpand
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Functional proteomics approach to investigate the biological activities of cDNAs implicated in breast cancer.
Functional proteomics approaches that comprehensively evaluate the biological activities of human cDNAs may provide novel insights into disease pathogenesis. To systematically investigate theExpand
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Abstract 943: SAR439859, an orally bioavailable selective estrogen receptor degrader (SERD) that demonstrates robust antitumor efficacy and limited cross-resistance in ER+ breast cancer
Despite resistance to endocrine therapies, estrogen receptor-positive (ER+) breast cancers (BC) still rely on ER. Eliminating ER by inducing its degradation with selective ER downregulators (SERD)Expand
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Insulin receptor-like tyrosine kinase in the tobacco hornworm, Manduca sexta.
Phosphotyrosine-containing proteins are present in the prothoracic glands, muscle, and fat body of Manduca sexta, as determined by immunoprecipitation followed by kinase assay, and by WesternExpand
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Cooperation of the ErbB 2 receptor and transforming growth factor in induction of migration and invasion in mammary epithelial cells
MCF10A mammary epithelial cells form growth-arrested structures when cultured in three-dimensional basement membrane gels. Activation of the receptor tyrosine kinase ErbB2 induces formation ofExpand
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Abstract P3-04-05: Identification of SAR439859, an orally bioavailable selective estrogen receptor degrader (SERD) that has strong antitumor activity in wild-type and mutant ER+ breast cancer models
Nearly 70% or more of newly diagnosed cases of breast cancer (BC) are estrogen receptor positive (ER+) where endocrine therapy is a primary treatment. However, substantial evidence describes aExpand
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THE IMPORTANCE OF BI IN CONTEMPORARY FINANCIAL SERVICES INDUSTRY
If there is anything that has happened consistently over the years than the inflation, it is the stiff competition in the global economy, more so in the financial services industry. The world hasExpand