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Our understanding of the plasma membrane, once viewed simply as a static barrier, has been revolutionized to encompass a complex, dynamic organelle that integrates the cell with its extracellular environment. Here, we discuss how bidirectional signaling across the plasma membrane is achieved by striking a delicate balance between restriction and propagation(More)
Cellular membranes are constantly reshaped by vesicular fission and fusion as well as by interactions with the dynamic cytoskeleton. Signaling activity at membranes depends on their geometric parameters, such as surface area and curvature; these affect local concentration and thereby regulate the potency of molecular reactions. A membrane's shape is thus(More)
KRas is a major proto-oncogene product whose signaling activity depends on its level of enrichment on the plasma membrane (PM). This PM localization relies on posttranslational prenylation for membrane affinity, while PM specificity has been attributed to electrostatic interactions between negatively charged phospholipids in the PM and basic amino-acids in(More)
Autocatalytic activation of epidermal growth factor receptor (EGFR) coupled to dephosphorylating activity of protein tyrosine phosphatases (PTPs) ensures robust yet diverse responses to extracellular stimuli. The inevitable tradeoff of this plasticity is spontaneous receptor activation and spurious signaling. We show that a ligand-mediated switch in EGFR(More)
We investigate experimentally a homogeneously driven granular medium. It consists of spheres, each one containing a magnetic dipole, rolling on a horizontally placed dish and subject to a magnetic field which is sinusoidal in time and spatially homogeneous. A gaslike state is obtained. Except for extremely low amplitudes of the magnetic field, non-Gaussian(More)
We present experimental evidence for a "granular clock." We use a setup in which vertical vibrations (10-20 Hz) of a bidisperse granular medium cause horizontal oscillations (periods in the order of minutes) between two connected compartments. Moreover, we present the first experimental evidence for full segregation of smaller particles into one(More)
Evidence for intermittency in a granular medium: experiments and simulations. We present the first experimental demonstration of intermittency in a granular medium. The medium consists of magnets embedded within spheres. These spheres are placed in a horizontal Petri dish where they roll by virtue of an alternating, homogenous magnetic field. Due to(More)
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