Malte Kohns

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The vast majority of Mycobacterium tuberculosis (M. tuberculosis) infected individuals are protected from developing tuberculosis and T cells are centrally involved in this process. MicroRNAs (miRNA) regulate T-cell functions and are biomarker candidates of disease susceptibility and treatment efficacy in M. tuberculosis infection. We determined the(More)
Remote ischemic preconditioning (RIPC) is an easily applicable method for protecting the heart against a subsequent ischemia and reperfusion (I/R) injury. However, the exact molecular mechanisms underlying RIPC are unknown. We examined the involvement of microRNAs (miRNAs) and in particular the expression of miRNA-1 (miR-1) in RIPC and myocardial ischemia.(More)
T-cell proliferation and generation of protective memory during chronic infections depend on Interleukin-7 (IL-7) availability and receptivity. Regulation of IL-7 receptor (IL-7R) expression and signalling are key for IL-7-modulated T-cell functions. Aberrant expression of soluble (s) and membrane-associated (m) IL-7R molecules is associated with(More)
BACKGROUND MicroRNAs (miRNAs) are crucial regulators of human immunity e.g. against Mycobacterium tuberculosis. Against the background of still alarming high mortality of tuberculosis effective biomarkers to improve diagnosis of M. tuberculosis infection and successful treatment are of major importance. CONCLUSIONS This review summarizes recent surrogate(More)
Die Tuberkulose – verursacht durch Erreger des Mycobacterium-tuberculosis-Komplexes – ist eine in Deutschland heute selten auftretende Infektionserkrankung. Nach einem kontinuierlichen Rückgang der Fälle über die letzten Jahrzehnte erreichte ihre Inzidenz einen stabil niedrigen Stand. Für den Haus- oder Kinderarzt wurde daher der Umgang mit Erkrankungs- und(More)
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