Malou Friederich-Persson

Learn More
Diabetic nephropathy is strongly associated with both increased oxidative stress and kidney tissue hypoxia. The increased oxidative stress causes increased kidney oxygen consumption resulting in kidney tissue hypoxia. To date, it has been difficult to determine the role of kidney hypoxia, per se, for the development of nephropathy. We tested the hypothesis(More)
Increased O(2) metabolism resulting in chronic hypoxia is common in models of endstage renal disease. Mitochondrial uncoupling increases O(2) consumption but the ensuing reduction in mitochondrial membrane potential may limit excessive oxidative stress. The present study addressed the hypothesis that mitochondrial uncoupling regulates mitochondria function(More)
rogressive loss of kidney function leads to end-stage renal disease (ESRD), requiring dialysis or kidney transplan-tation. Diabetes mellitus, hypertension, glomerulonephritis, and cystic kidney disease are all major causes for ESRD. 1 Approximately 45% of all cases of ESRD are caused by diabetes mellitus, 2 and the number of affected patients will continue(More)
  • 1