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Meiotic recombination in the yeast Saccharomyces cerevisiae is initiated by programmed double-strand breaks at selected sites throughout the genome (hotspots). alpha-Hotspots are binding sites for transcription factors. Double-strand breaks at alpha-hotspots require binding of transcription factor but not high levels of transcription per se. We show that(More)
Mismatches, and the proteins that repair them, play multiple roles during meiosis from generating the diversity upon which selection acts to preventing the intermingling of diverged populations and species. The mechanisms by which the mismatch repair proteins accomplish these many roles include gene conversion, reciprocal crossing over, mismatch(More)
BACKGROUND AND AIMS Mismatch repair proteins play important roles during meiotic recombination in the budding yeast Saccharomyces cerevisiae and most eukaryotic organisms studied to date. To study the functions of the mismatch repair protein Mlh2p in meiosis, we constructed mlh2Delta strains and measured rates of crossing over, gene conversion, post-meiotic(More)
Four different goat breeds (Pak-Angora, Dera Din Panah, Naachi and Teddy) of Pakistan were selected to investigate polymorphism in the prion protein gene (PrP gene) responsible for scrapie disease resistance in goats. Initially, genotyping of 187 animals of these four breeds by restriction fragment length polymorphism (RFLP) was done to see the genotype for(More)
Various studies have shown contradicting results in p27 and cyclin D1 protein expression and the association with brain tumors. This study was thus performed to address new information of both markers' expression in gliomas and meningiomas cases, among Malaysian brain tumors patients. For these purposes, 24 meningiomas and 23 gliomas were analyzed by(More)
The Fuzzy hybridization technique for intelligent systems have become of research interests in a variety of research areas over the past decade. There are limitations faced by all popular fuzzy systems architectures when they are applied to applications with a large number of inputs (more than three). The present paper proposes a novel adaptive fuzzy(More)
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