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UNLABELLED Genomic analyses are yielding a host of new information on the multiple genetic abnormalities associated with specific types of cancer. A comprehensive description of cancer-associated genetic abnormalities can improve our ability to classify tumors into clinically relevant subgroups and, on occasion, identify mutant genes that drive the cancer(More)
Large-scale genomic studies have identified multiple somatic aberrations in breast cancer, including copy number alterations and point mutations. Still, identifying causal variants and emergent vulnerabilities that arise as a consequence of genetic alterations remain major challenges. We performed whole-genome small hairpin RNA (shRNA) "dropout screens" on(More)
In 31 anesthetized dogs, the distribution volume (Vd) of indocyanine green (ICG, Cardiogreen) was compared to that of Evans blue (EB), which is considered to represent plasma volume. Vd was computed from the injected amount of indicator and the indicator concentration in plasma at time zero, which was obtained by extrapolation of the monoexponential decay(More)
We critically review the various methods for assessing protein--calorie malnutrition. These tests are lacking in sensitivity and specificity, and currently no single one can be used as a reliable indicator of malnutrition. However, a combination of several of them can be used as prognostic indicators and are of help in selecting patients who may benefit(More)
Pregnancy-associated plasma protein-A and -A2 (PAPPA and PAPPA2) are proteases that cleave IGF binding proteins (IGFBPs) and thereby increase the bioavailability of growth factors. PAPPA has long been recognized as a marker of fetal genetic disorders and adverse pregnancy outcomes. In contrast, although PAPPA2 is also highly expressed in human placenta, its(More)
Richard Marcotte*, Kevin R. Brown*, Fernando Suarez*, Azin Sayad, Konstantina Karamboulas,Paul M. Krzyzanowski, Fabrice Sircoulomb, Mauricio Medrano, Yaroslav Fedyshyn, Judice L.Y. Koh,Dewald van Dyk, Bodhana Fedyshyn, Marianna Luhova, Glauber C. Brito, Franco J. Vizeacoumar, Frederick S. Vizeacoumar, Alessandro Datti, Dahlia Kasimer, Alla Buzina, Patricia(More)
In 301 patients admitted to an intensive-care unit because of acute myocardial infarction a prognostic analysis was undertaken, based on 21 parameters (history, condition on admission, laboratory results) and related to ultimate outcome. Although some parameters were singly of prognostic value, discrimination analysis markedly improved predictive value. A(More)
PEEP impedes thoracic duct drainage (LF). This can be counteracted by a thoracic duct fistula. Consequently, lung oedema (LOE) should develop during PEEP more slowly with LF at atmospheric pressure (LFAP) than with LF against jugular venous pressure (LFJVP). In 12 anaesthetized dogs LOE was produced by Ringer's solution i.v. (2.5 ml/min per kg) for 6 h(More)
The effect of positive end-expiratory pressure ventilation (PEEP, 11-12 mmHg, 60-90 min without, 19 h with circulatory support) on fractional escape rate of plasma proteins (FER), and on thoracic duct lymph flow draining against jugular venous (LFJVP) or atmospheric pressure (LFAP) was studied in anaesthetized dogs. FER was 10.8%/h, 15.3%/h, and 8.5%/h(More)